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Identification and selection of at least one cord blood unit for transplantation

An umbilical cord blood and serology technology, applied in patient-specific data, personal medical record data management, special data processing applications, etc., can solve the problems of no public multiple transplant solutions, no further standards, etc.

Inactive Publication Date: 2013-03-27
CYTOLON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art discloses selection of suitable preparations based primarily on HLA typing and provides essentially no further criteria
[0014] Additionally, the prior art does not disclose any solution for multiple transplantation

Method used

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  • Identification and selection of at least one cord blood unit for transplantation
  • Identification and selection of at least one cord blood unit for transplantation
  • Identification and selection of at least one cord blood unit for transplantation

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Experimental program
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preparation example Construction

[0134] The first sorting criterion for this multiple cord blood matching between registered preparations is HLA matching, but it may also be preferred that the first sorting criterion be blood type or TNC count. Preferably there is a match in at least 4 of the 6 HLA signatures, and those preparations with the most HLA matches are at the top of the order suitable as multiple cord blood. The system is able to calculate incompatibilities and provide a clear representation of them. Certain characteristics that increase the risk of rejection can be identified. Early identification of this risk (ie, before transplantation) can avoid incompatible preparations during selection. If no alternative preparations are available, early initiation of treatment can reduce or even completely suppress rejection. Surprisingly, due to this sorting criterion, the system is able to use only sufficiently compatible UCB preparations for transplantation.

[0135] Within the meaning of the present in...

Embodiment 1

[0213] Example 1, Table 3: Cord blood units with serological and molecular values ​​for different loci:

[0214]

[0215]

Embodiment 2

[0216] Example 2, Table 4: Cord Blood Units with Serological and Molecular Values ​​for the Same Gene Loci:

[0217]

[0218] Verification of HLA values

[0219] For molecular high resolution values, the value is checked against the full code and the matching relevant part of the code in Table DNA-SER. For molecular medium and low resolution values, the value is checked in the first step for the allelic type (eg A*01:) according to table DNA-SER. For generic molecular medium resolution values, check in the second step if this code is listed in the allele table, eg: A*01:AA->AA is in the mapping table. For allele-specific molecular medium resolution values, if this code is listed in the allele table and the value is valid for this code, e.g. B*13:BM->BM is in the mapping table and there is at least one band There is a code of B*13, which is checked in the second step. For molecular low resolution values, if the allelic subtype is "XX", it is checked in the second step. F...

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Abstract

The invention describes a method for the identification and selection for at least one cord blood unit for a transplantation.

Description

technical field [0001] The present invention relates to methods and systems for identifying and selecting at least one cord blood unit for transplantation. Background technique [0002] Cord blood is playing an important and growing role in the treatment of leukemia, lymphoma and other fatal blood disorders. [0003] Cord blood is one of 3 sources of hematopoietic cells used in transplantation. The other two sources are bone marrow and peripheral (circulating) blood. The first cord blood (CB) transplant was performed in 1988. Today, cord blood plays an important role in transplants. Cord blood is collected from the umbilical cord and placenta after the baby is born. This blood is rich in hematopoietic cells. [0004] After donation, the cord blood is tested, frozen and stored at a cord blood bank for future use. Banked cord blood is called a cord blood unit (CBU). [0005] Like bone marrow, cord blood is rich in hematopoietic cells that can be used for transplantation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/24G16B20/20G16B40/20G16B50/00
CPCG06F19/32G06F19/24G06F19/28G06F19/18G06F19/322G16H10/60G16B20/00G16B40/00G16B50/00G16H70/00G16B20/20G16B40/20
Inventor 托马斯·克莱因
Owner CYTOLON