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New usages of lotus plumule and alkaloid thereof and derivative thereof

A technology of lotus seed heart and usage, applied in the field of medicine, can solve the problem of no specific drug treatment for diseases

Inactive Publication Date: 2013-05-01
李宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug treatment for these diseases

Method used

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  • New usages of lotus plumule and alkaloid thereof and derivative thereof
  • New usages of lotus plumule and alkaloid thereof and derivative thereof
  • New usages of lotus plumule and alkaloid thereof and derivative thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 The preparation of Lianxin total alkaloids of the present invention

[0032] Take the lotus seed heart, crush it, add 2 to 6 times of water, decoct 3 times, 0.5 to 2 hours each time, combine the filtrate, reflux to concentrate, filter, add 2 to 8 times of ethanol, so that the ethanol concentration in the water extraction solution reaches 50 to 60% . Let it stand for 12-24 hours, filter, and recover the ethanol from the filtrate under reduced pressure, concentrate it to a relative density of 1.20-1.40, dry it under reduced pressure, and obtain the lotus seed extract, that is, the total alkaloids of lotus heart. The content is determined by ultraviolet spectrophotometry, and the result: the weight percentage of the total alkaloids is 30-70%, and the weight percentage is 1-30% based on liensinine.

[0033]

Embodiment 2

[0034] The preparation of embodiment 2 Lianxin total alkaloids of the present invention

[0035] Take the lotus heart, crush it, use 2-5 times the amount of 70-85% ethanol to reflux extract 2-4 times, each time reflux extraction for 0.5-1.5h, filter the combined filtrate, recover ethanol under reduced pressure, and the relative density of concentration is 1.01-1.10 of concentrate. Use sulfuric acid to adjust the pH of the concentrated solution to 2.0-4.0, let it stand still, centrifuge, use 10-20% ammonia to alkalinize the centrifuged solution to adjust the pH to 8-10, let it stand still, filter to collect the precipitate, add ethanol to heat to dissolve, stand still, filter, The filtrate is recovered under reduced pressure to ethanol to the maximum, concentrated to a relative density of 1.20-1.40, and dried under reduced pressure to obtain the lotus heart extract, which is the total alkaloids of lotus heart. The total alkaloid content is 10% to 50%, accounting for 1% to 10% ...

Embodiment 3

[0037] The preparation of embodiment 3 Lianxin total alkaloids of the present invention

[0038] Take the lotus heart, crush it, put it into a percolator, add 2-6‰HCl to impregnate and expand for 24-48h, then add new 2-6‰HCl continuously, let it permeate through the medicinal material from top to bottom, from the lower part of the percolator Flow out and collect the leachate, combine all filtrates, alkalinize with 10-20% ammonia to pH 8-10, filter to obtain precipitate, and dry under reduced pressure to obtain total alkaloids of lotus heart, with a total alkaloid content of 2-30%. Alkali accounted for 1 to 15%. The content was determined by UV spectrophotometry.

[0039]

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Abstract

The invention provides new usages of lotus plumule and alkaloid thereof and derivative thereof, such as lotus total alkaloids, liensinine, isoliensinine and methyl liensinine, in particular to the usages of lotus plumule and extract thereof, lotus plumule total alkaoids, bis-benzyl-isoquinoline alkaloid derivative or analogue in preparing drugs for curing senile dementia or healthcare food or food additives. The new usages are characterized in that the lotus plumule and extract thereof, the lotus plumule total alkaoids, the bis-benzyl-isoquinoline alkaloid derivative or the analogue are adopted as main active ingredients, and other compatible active ingredients are combined to form a new formula to prevent and treat dementia (including senile dementia and vascular dementia), improve learning and memory and the like. The dosage forms can be solid forms, liquid forms and the like used for different administrations such as oral taking, sublingual administration, nasal mucosa administration, percutaneous administration, muscle administration, vein administration and rectum administration.

Description

technical field [0001] The invention provides lotus root and its alkaloids and its derivatives, specifically, the use of lotus root and its extracts, lotus root alkaloids, bisbenzylisoquinoline alkaloid derivatives or analogues, belonging to the field of medicine . Background technique [0002] Alzheimer's disease, also known as Alzheimer's disease (AD), is a primary degenerative brain disease that occurs in the elderly and pre-senile. The etiology and pathogenesis of many factors are involved, such as genetics, environment, aging , metabolism, history of head trauma, estrogen deficiency, etc. The clinical manifestations are progressive memory impairment, decline in analysis and judgment, emotional changes, abnormal behavior, and even confusion. At present, the prevalence rate of the elderly over 65 years old in our country is as high as 6.6%. Every time the age increases by 5 years, the prevalence rate doubles. For the elderly over 80 years old, as high as 20% suffer from...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/62A61K31/4725A61P25/28A23L1/30
Inventor 马松涛李宏
Owner 李宏
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