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Drug against central nervous system inflammation

A central nervous system, drug technology, applied in nervous system diseases, neuromuscular system diseases, anti-inflammatory agents, etc., can solve problems such as brain damage, death, coma, etc.

Active Publication Date: 2013-05-22
FUJINO BRAIN RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, when inflammation due to bacterial or viral encephalitis significantly damages the brain, it may lead to frequent occurrences of confusion, convulsions, and coma, depending on the species of bacteria or virus; in the case of more severe cases, its may even result in death
Also, even if the patient recovers, the patient may still suffer from permanent neurological impairment due to nerve cell damage

Method used

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  • Drug against central nervous system inflammation
  • Drug against central nervous system inflammation
  • Drug against central nervous system inflammation

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0170] Preparation Example 1: Preparation of Fraction Containing Plasmalogen Extracted from Biological Tissue

[0171] Chicken skin, which is a poultry tissue, was collected according to a currently known method, cut into minced meat with a size of about 8 mm, and then heated and compressed using a press to remove neutral lipids, thereby preparing defatted chicken skin. The defatted chicken skin is then freeze-dried and crushed by a conventional method, thereby obtaining the defatted chicken skin dry powder. The defatted chicken skin dry powder is stored airtightly together with a deoxidizer until it is used for extraction.

[0172] Organic solvent extraction steps

[0173] step 1)

[0174] To 1 kg of the dry chicken skin powder obtained above was added 2 L of ethanol, and the resulting solution was stirred at 40° C. for 12 hours, and left to stand. Afterwards, the extraction solution is separated from the solid. 2 L of ethanol was added to the solid, and extraction was ...

Embodiment 1

[0192] Example 1: Investigation of central inflammation prevention effect of plasmalogen extracted from biological tissue

[0193] The following experiment was carried out to investigate the effect of plasmalogen extracted from poultry tissue on central nervous system inflammation.

[0194] Preparation of model mice and administration of test substances

[0195] Brain inflammation model mice were generated in the same manner as in Non-Patent Document 2 (Lee JW et al., Neuroinflammation. 2008-29; 5:37). More specifically, LPS (lipopolysaccharide), which is a stimulator of TLR4 (Toll-like receptor 4), was intraperitoneally administered to mice for several consecutive days, thereby generating chronic brain inflammation model mice.

[0196] Specifically, four male C57BL mice (Kyudo Co., Ltd.) aged 8 to 12 weeks were intraperitoneally administered LPS (250 μg / kg, Sigma Aldrich) once a day for seven consecutive days, thereby obtaining brain inflammation model mice . A control g...

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Abstract

The purpose of the present invention is to provide a novel method which has an effect of ameliorating central nervous system inflammation. Provided is a drug against central nervous system inflammation which comprises a plasmalogen. Particularly preferably provided is a drug against central nervous system inflammation which comprises a plasmalogen extracted from a biotissue (preferably an avian tissue) containing ethanolamine plasmalogen and choline plasmalogen.

Description

technical field [0001] The invention relates to a medicine for anti-inflammation of the central nervous system comprising plasmalogen. More specifically, the present invention relates to an anti-inflammation drug of the central nervous system, which contains plasmalogen extracted from biological tissue as an active ingredient. The anti-inflammation drugs of the central nervous system can also be referred to as drugs for preventing and / or treating inflammation of the central nervous system. Background technique [0002] The central nervous system is a collection of many nerve cells such as the brain, spinal cord, etc. in vertebrates. These nerve cells are covered and protected by the brain or meninges. There are various causes of central nervous inflammation (inflammation of the central nervous system: encephalitis, myelitis, meningitis, etc.). For example, acute or chronic encephalitis, myelitis, meningitis, etc. can be caused by fungal, bacterial or viral infection. In ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/661A61K31/685A61P21/00A61P25/00A61P25/16A61P25/18A61P25/24A61P25/28A61K35/57
CPCC07F9/222A61K31/661A61K35/57A61K31/685A61P21/00A61P25/00A61P25/16A61P25/18A61P25/24A61P25/28A61P29/00
Inventor 马渡志郎藤野武彦井福正隆杉山雅昭府中英孝
Owner FUJINO BRAIN RES
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