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Anti-cancer pharmaceutical composition, and preparation method as well as application thereof

A composition and drug technology, applied in the field of anticancer pharmaceutical composition and its preparation and use, to achieve the effects of improving pathophysiological environment, controlling complications and preventing recurrence

Active Publication Date: 2015-04-08
ZHONGSHAN FLASHLIGHT POLYTECHNIC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not many traditional Chinese medicine preparations that can be used clinically to treat CC. Among the 5017 preparations contained in the "New National Chinese Patent Medicine", only Aidi Injection, Compound Mylabris Capsules, Kangaiping Pills, Xiaoaiping Tablets and Syrup, Zhemu Several Chinese patent medicines such as syrup have the effect of treating CC

Method used

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  • Anti-cancer pharmaceutical composition, and preparation method as well as application thereof
  • Anti-cancer pharmaceutical composition, and preparation method as well as application thereof
  • Anti-cancer pharmaceutical composition, and preparation method as well as application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 pharmaceutical composition of the present invention---capsule

[0024] Take 15g of Sophora flavescens, 10g of rhubarb, and 2g of Panax notoginseng, add 8 times the amount of 70% ethanol to reflux and extract twice, each time for 1 hour, combine the extracts, recover ethanol under reduced pressure and concentrate to an extract with a relative density of 1.2-1.3, Vacuum-dried, pulverized, and filled into capsules, 0.3g per capsule, to obtain.

Embodiment 2

[0025] The preparation of embodiment 2 pharmaceutical compositions of the present invention—oral liquid

[0026] Take 7g of Sophora flavescens, 17g of rhubarb, and 8g of Panax notoginseng, add 8 times the amount of 70% ethanol to reflux and extract twice, each time for 1 hour, combine the extracts, recover ethanol under reduced pressure, add water to dilute to 60ml, filter, and use 10ml per branch Subpackage, that is.

Embodiment 3

[0027] The preparation of embodiment 3 pharmaceutical composition of the present invention---granule

[0028] Take 11g of Sophora flavescens, 13g of rhubarb, and 5g of Panax notoginseng, add 8 times the amount of water to decoct and extract 3 times, each time for 0.5 hours, combine the extracts, concentrate, add dextrin and starch to granulate, and obtain.

[0029] The beneficial effects of the present invention are illustrated below through specific test examples.

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Abstract

The invention provides an anti-cancer pharmaceutical composition, which is the preparation prepared by the following active ingredients in parts by weight: 5-15 parts of radix sophorae flavescentis, 0-20 parts of rheum officinale and 0-10 parts of pseudo-ginseng, wherein the dosage of rheum officinale and pseudo-ginseng are not simultaneously zero. The invention further provides a preparation method and an application of the anti-cancer pharmaceutical composition. By adopting the compatibility of medicines of sophorae flavescentis, rheum officinale and pseudo-ginseng, the synergistic effect is provided, the anti-cancer activity of single medicine or medicine pair is significantly improved, and a novel selection is provided for the treatment of Chinese traditional treatment for colon cancer.

Description

technical field [0001] The invention relates to an anticancer pharmaceutical composition, its preparation method and application. Background technique [0002] Cancer, also known as malignant tumor (Malignant neoplasm), is a disease caused by the abnormal mechanism of controlling cell growth and proliferation. In addition to growing out of control, cancer cells can also locally invade the surrounding normal tissues and even transfer to other parts of the body through the internal circulatory system or lymphatic system. Common cancers include gastric cancer, colon cancer, liver cancer, nasopharyngeal cancer, lung cancer, and intracranial tumors. Among them, colon cancer (CC) refers to malignant tumors that occur in the cecum, ascending colon, transverse colon, descending colon, and sigmoid colon. In recent years, with the improvement of living standards and changes in living habits, the incidence of colon cancer in my country is also on the rise, ranking second only to gast...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61P35/00A61P1/00
Inventor 赵斌王琼刘敬陈念熊文明李拥军王建国谢彩玲郭佛杨
Owner ZHONGSHAN FLASHLIGHT POLYTECHNIC
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