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Method for determining serous metabolic biomarker of heroin abuse crowd

A technology for metabolic markers and heroin, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve the effects of convenient operation, sensitive determination, and easy implementation

Inactive Publication Date: 2013-07-10
CHINA PHARM UNIV +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, there is no report on the use of metabolomics detection methods to detect molecules in serum to quickly determine the degree of drug abuse

Method used

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  • Method for determining serous metabolic biomarker of heroin abuse crowd
  • Method for determining serous metabolic biomarker of heroin abuse crowd
  • Method for determining serous metabolic biomarker of heroin abuse crowd

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0015] The present invention is explained in detail by the following examples, but it does not mean that the present invention is limited thereto.

[0016] Determination method of serum metabolic markers for rapid diagnosis of heroin abuse

[0017] 1. Experimental Protocol and Sample Collection

[0018] 39 healthy people (23 males, 16 females) and 40 heroin abusers (31 males, 9 females) recorded their gender, age, and years of abuse, respectively, and screened liver and kidney function indicators, including gluten C, gluten , glutamyl, blood urea nitrogen, creatinine, and blood sugar levels were confirmed to be within the normal range. According to the years of abuse, patients were divided into three stages: short-term abuse, medium-term abuse, and long-term abuse. Healthy volunteers and heroin abusers collected 1ml of blood on an empty stomach in the morning and put it into a gel tube. After centrifugation at 3500rpm, the supernatant serum was collected and stored at -80°C. ...

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Abstract

The invention discloses a method for determining a serous metabolic biomarker of a heroin abuse crowd, which is implemented mainly through that by using analysis techniques and methods based on gas chromatography / mass spectrum and liquid chromatography-mass spectrum and the like, endogenous small molecular compounds are quantitatively determined, and by calculating and comparing the relative concentration difference between the endogenous small molecule compounds of a heroin abuse crowd and a healthy crowd, the metabolic biomarker concentration ranges of the two sets of crowds are respectively determined; and the method is applied to the clinical identification of heroin abuse crowds. Compared with the existing other identification methods, the method is wide in adaptive range, sensitive, convenient for sampling, and simple in operation, and has no harm to the body. The method solves the problem of the absence of clinical indicators for heroin abuse clinically, and facilitates the identification of clinical heroin abusers and the improvement of identification accuracy.

Description

technical field [0001] The invention relates to a method for measuring diagnostic markers of heroin abuse, in particular to detecting endogenous small molecules in human blood samples by using gas chromatography mass spectrometry and liquid chromatography mass spectrometry, and using relative quantitative or absolute quantitative methods to measure endogenous molecules in the serum of heroin abusers. Sexual small molecules, compared with the range of small molecule content in normal human serum, as the basis for evaluation. Background technique [0002] For a long time, there have been some problems in the actual work of public security on how to judge the standards of addiction to smoking and injecting drugs. Medically, the judgment of drug addiction by taking and injecting drugs is mainly based on the CCMD-3, DSM-IV, and ICD-10 drug dependence standards. However, after analyzing these three standards in detail, it is found that the contents are all subjective judgments, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 王广基阿基业郑天周亚红刘林生
Owner CHINA PHARM UNIV
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