New production technology of bovine pancreatin

A production process, the technology of bovine pancreatin, which can be applied to pancreatin and other directions, can solve the problems of increasing subsequent processing, environmental pollution, waste, etc., and achieve the effects of good application and promotion prospects, short production cycle and high enzyme activity.

Active Publication Date: 2013-07-24
CHONGQING AOLI BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

my country is a large animal husbandry production country, but more than 90% of cattle pancreas is discarded, which not only causes waste, but also increases the follow-up treatment of enterprises and environmental pollution. It is necessary to develop and provide high efficiency, high enzyme activity, stable properties, short production cycle, The low-cost bovine pancreatin extraction process turns bovine pancreas from waste into treasure, which can produce obvious economic benefits

Method used

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  • New production technology of bovine pancreatin
  • New production technology of bovine pancreatin
  • New production technology of bovine pancreatin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Production process of bovine pancreatin

[0028] (1) Thawing raw materials, shavings, and refining: accurately weigh the quarantined frozen bovine pancreas and the pig duodenum with 1% weight of the bovine pancreas and shred them with a pancreaser, and then refine them with a refiner.

[0029] (2) Activation, extraction and filtration: Put the pancreatic plasma in the reaction axe, add 0.6% edible calcium chloride and 0.5% pancreatin powder as the activator by weight of the pancreas, and then add 1.5 times the weight of the pancreas with a concentration of 15% The aqueous acetone solution was stirred for 30 minutes, put into the extraction tank, temperature 15 ℃, extraction for 6 hours, filtered with a separator, the filter residue was extracted again in the same way, the two extracts were combined, and the filter residue was discarded to obtain pancreatic milk filtrate.

[0030] (3) Precipitation and pressing: Add acetone (0.85 lighter than the concentration) solution pre-...

Embodiment 2

[0074] Example 2. Production process of bovine pancreatin

[0075] (1) Thawing raw materials, shavings, and refining: accurately weigh the quarantined frozen bovine pancreas and 5% of the weight of the pig duodenum of the bovine pancreas with a pancreas planer, and then use a refiner to refine.

[0076] (2) Activation, extraction and filtration: Put the pancreatic plasma in the reaction axe, add 0.8% pancreatic weight edible calcium chloride and 0.5% pancreatin powder as the activator, and then add 0.5 times the pancreatic weight with a concentration of 10% The acetone solution was stirred for 50 minutes, put into the extraction tank, temperature 20 ℃, extraction for 5 hours, filtered with a separator, the filter residue was extracted again in the same way, the two extracts were combined, and the filter residue was discarded to obtain pancreatic milk filtrate.

[0077] (3) Precipitation and squeezing: Add acetone (0.85 lighter than the concentration) solution pre-cooled to -5°C into ...

Embodiment 3

[0089] Example 3. Production process of bovine pancreatin

[0090] (1) Thawing raw materials, shavings, and refining: accurately weigh the quarantined frozen bovine pancreas and pig duodenum with 3% of the weight of the bovine pancreas and shred them with a pancreaser, and then refine them with a refiner.

[0091] (2) Activation, extraction and filtration: Put the pancreatic plasma in the reaction axe, add 1% edible calcium chloride and 1% pancreatin powder as an activator by weight of the pancreas, and then add 2 times the weight of the pancreas with a concentration of 10% The acetone solution was stirred for 60 minutes, put into the extraction tank, the temperature was 10 ℃, the extraction was 8 hours, filtered with a separator, the filter residue was extracted again in the same way, the two extracts were combined, and the filter residue was discarded to obtain pancreatic milk filtrate.

[0092] (3) Precipitation and squeezing: Add acetone (0.85 lighter than the concentration) solu...

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Abstract

The invention discloses a new production technology of bovine pancreatin and belongs to the medicine manufacturing technology. The new production technology comprises the steps of raw material treatment, activation, extraction, precipitation, degreasing, drying and grinding and is characterized in that the steps of activation and extraction further comprise the sub-steps of: adding calcium chloride accounting for 0.5-1% of the weight of the raw material and pancreatin powder accounting for 0.5-1% of the weight of the raw material into pancreatic pulp as activators; adopting 10-20% (v / v) acetone solution which is 0.5-2 times the weight of the raw material as an extractant; stirring for 30-60 minutes; extracting at 10-20 DEG C for 10-15 hours; filtering with a separator; and discarding the filter residue to obtain pancreatic milk filtrate; and then other steps are performed. The new production technology disclosed by the invention has the characteristics of high extraction efficiency, high enzyme activity, stable properties and short production period, turns waste into wealth, produces obvious economic benefits, and has good application and popularization prospect in the fields of food, leather, washing and cleaning, medicine and the like.

Description

Technical field [0001] The invention belongs to medicine manufacturing technology, and particularly relates to a new production process of bovine pancreatin. Background technique [0002] Pancreatin is a digestive aid included in the pharmacopoeias of various countries. It is a mixture of various enzymes extracted from animal pancreas. The main components are trypsin, pancrelipase and pancreatic amylase. Pancreatin is mainly used for indigestion, loss of appetite and digestive disorders caused by liver and pancreatic diseases. It is also suitable for pancreatic insufficiency caused by congenital pancreatic insufficiency, abdominal surgery and traumatic pancreatectomy. In addition, pancreatin contains a variety of active substances, which can be used as basic raw materials to extract a variety of biochemical drugs, such as pancreatic kinininogen, elastase, asparaginase, chymotrypsin, carboxypeptidase, etc. [0003] Pancreatin has great industrial value. At present, the production o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N9/94
Inventor 冉崇荣朱占权陈曾兰乾
Owner CHONGQING AOLI BIOPHARM
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