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Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof

Disinfectant and microemulsion technology, applied in the field of disposable antibacterial skin and hand microemulsion disinfectant, disposable skin and hand microemulsion disinfectant preparation and preparation fields, can solve the problem of high irritation, stinging, allergic reaction, etc. question

Active Publication Date: 2013-08-07
XUZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are two types of skin and hand disinfectants commonly used at home and abroad: one is ethanol, iodine, tincture of iodine and other disinfectants. Humans have allergic reactions after use, and are not suitable for long-term use on skin and hands; the other is a compound disinfectant of chlorhexidine acetate and ethanol, but the concentration of ethanol is as high as 50%-70%, so it has a strong pungent smell , and after use, the skin and hands will be dry and produce rashes, etc. The protective effect on the skin needs to be improved

Method used

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  • Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof
  • Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] After heating and stirring 4.5g of chlorhexidine acetate, 0.2g of domiphene and 12.0g of medium-chain triglycerides in the prescribed quantity, add the surfactant (Cremophor ELP ) 160.0g, stir quickly and evenly to obtain the oil phase; add 10.0g of glycerin and 100.0g of ethanol to the prescription amount of distilled water, heat to the same temperature as the oil phase, and obtain the water phase; under the condition of constant temperature magnetic stirring , mix the water phase and oil phase in a closed container at 20°C-40°C, and stir for 60 minutes to obtain 1.0L of microemulsion; after cooling the microemulsion to room temperature, adjust the pH to 6.60, and store at room temperature.

Embodiment 2

[0019] After heating and stirring 3.5g of chlorhexidine acetate, 0.6g of domiphene and 14.0g of Arlacel86 in the prescription quantity, add the surfactant (polyethylene glycol dodecyl hydroxy stearic acid ester) 180.0g, stir quickly and evenly to obtain the oil phase; add glycerin 30.0g and ethanol 250.0g of the prescription amount to the distilled water of the prescription amount, and heat to the same temperature as the oil phase to obtain the water phase; Under stirring conditions, mix the water phase and oil phase in a closed container at 20°C-40°C, stir for 60 minutes to obtain 1.0L of microemulsion; after cooling the microemulsion to room temperature, adjust the pH to 6.20, and store at room temperature.

Embodiment 3

[0021] After heating and stirring 1.5g of chlorhexidine acetate, 1.0g of domiphene and 9.0g of medium-chain triglycerides in the prescription amount, add the surfactant (poloxa) dissolving 10.2g of grape polyphenols and 5.0g of quercetin Mu 188) 120.0g, stir quickly and evenly to obtain an oil phase; add 40.0g of glycerin and 200.0g of ethanol to the prescribed amount of distilled water, and heat to the same temperature as the oil phase to obtain a water phase; Under certain conditions, mix the water phase and the oil phase in a closed container at 20°C-40°C and stir for 60 minutes to obtain 1.0L of microemulsion; after cooling the microemulsion to room temperature, adjust the pH to 5.80 and store at room temperature.

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Abstract

The invention relates to clean-free skin and hand micro-emulsion disinfectant agent, and in particular relates to a clean-free skin and hand micro-emulsion disinfectant agent and a preparation method thereof. Under the situation of guaranteeing the effective sterilization, the concentration of ethanol is controlled to be less than 30 percent. Active sterilizing components of the disinfectant agent are chlorhexidine acetate and domiphen bromide, wherein the domiphen bromide has a surface active effect, the ethanol is used as an auxiliary surfactant and a propellant, and a skin and hand micro-emulsion disinfectant solution with the granularity of 1 to 200nm is prepared from injection oil, the surfactant and natural moistening skincare components. The skin and hand micro-emulsion disinfectant solution is practical, simple, high in safety, good in stability and low in thrilling, nano-grade particles form a protection film on a disinfected part, the sterilizing efficacy is high, the added natural moistening skincare component can deeply moisten and whiten the skin, the symptoms such as dry and dry itching caused by utilizing the disinfectant solution with high ethanol content for a long time can be remarkably improved, and an effect for protecting the skin and the hands can be realized.

Description

technical field [0001] The invention relates to a no-wash antibacterial skin hand microemulsion disinfectant, in particular to a no-wash skin hand microemulsion disinfectant preparation and a preparation method thereof. The disinfectant preparation can kill intestinal pathogenic bacteria, pyogenic cocci, pathogenic yeast and common bacteria in hospital infection, has a disinfection effect on the skin, and has high moisturizing properties and reduces local allergic reactions. It belongs to the technology of pharmaceutical preparations field. Background technique [0002] With the improvement of people's living standards and the rapid improvement of residents' awareness of disinfection, the demand for disinfection products is also increasing. The skin is the first barrier between the body and the outside world. As residents enter and exit public places such as medical institutions, banks, restaurants, entertainment venues, schools, offices, etc., as well as conduct business t...

Claims

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Application Information

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IPC IPC(8): A61K31/155A61K9/107A61P17/00A61P31/04A61K31/14
Inventor 刘毅刘莉田霞李静李赛孟文琪崔文
Owner XUZHOU MEDICAL COLLEGE
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