Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof

Disinfectant and microemulsion technology, applied in the field of disposable antibacterial skin and hand microemulsion disinfectant, disposable skin and hand microemulsion disinfectant preparation and preparation fields, can solve the problem of high irritation, stinging, allergic reaction, etc. question

Active Publication Date: 2013-08-07
XUZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are two types of skin and hand disinfectants commonly used at home and abroad: one is ethanol, iodine, tincture of iodine and other disinfectants. Humans have allergic reactions after use, and are not suitable for long-term use on skin and hands; the other

Method used

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  • Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof
  • Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0016] Embodiment 1,

[0017] After heating and stirring 4.5 g of chlorhexidine acetate, 0.2 g of dumiphene and 12.0 g of medium-chain triglycerides in the prescribed amounts, add a surfactant (Cremophor ELP) that dissolves 13.0 g of ginsenoside extract and 8.0 g of quercetin. ) 160.0g, stir quickly to get the oil phase; add 10.0g of glycerol and 100.0g of ethanol in the recipe amount to the distilled water of the recipe amount, heat to the same temperature as the oil phase, get the water phase; under the condition of constant temperature magnetic stirring , Mix the water phase and the oil phase in an airtight container at 20°C-40°C and stir for 60min to obtain 1.0L of microemulsion; after cooling the microemulsion to room temperature, adjust the pH to 6.60 and store at room temperature.

Example Embodiment

[0018] Embodiment 2,

[0019] After heating and stirring 3.5 g of chlorhexidine acetate, 0.6 g of dumiphene and 14.0 g of Arlacel 86 in the prescribed quantities, add a surfactant (polyethylene glycol dodecyl hydroxyl group) that dissolves 6.0 g of resveratrol and 10.0 g of quercetin. Stearic acid ester) 180.0g, stir quickly to obtain the oil phase; add glycerol 30.0g and ethanol 250.0g of the recipe to the distilled water of the recipe, and heat to the same temperature as the oil phase to obtain the water phase; Under stirring conditions, the water phase and the oil phase were mixed in an airtight container at 20°C-40°C, and stirred for 60 min to obtain 1.0 L of microemulsion; after cooling the microemulsion to room temperature, adjust the pH to 6.20 and store at room temperature.

Example Embodiment

[0020] Embodiment 3,

[0021] After heating and stirring 1.5g of chlorhexidine acetate, 1.0g of dumiphene and 9.0g of medium-chain triglycerides in the prescribed quantities, add a surfactant (Poloxa) that dissolves 10.2g of grape polyphenols and 5.0g of quercetin. Mu 188) 120.0g, stir quickly to get the oil phase; add 40.0g of glycerol and 200.0g of ethanol in the recipe amount to the distilled water of the recipe amount, and heat to the same temperature as the oil phase to obtain the water phase; Under the conditions, the water phase and the oil phase were mixed in an airtight container at 20°C-40°C, and stirred for 60 minutes to obtain 1.0 L of microemulsion; after the microemulsion was cooled to room temperature, the pH was adjusted to 5.80 and stored at room temperature.

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Abstract

The invention relates to clean-free skin and hand micro-emulsion disinfectant agent, and in particular relates to a clean-free skin and hand micro-emulsion disinfectant agent and a preparation method thereof. Under the situation of guaranteeing the effective sterilization, the concentration of ethanol is controlled to be less than 30 percent. Active sterilizing components of the disinfectant agent are chlorhexidine acetate and domiphen bromide, wherein the domiphen bromide has a surface active effect, the ethanol is used as an auxiliary surfactant and a propellant, and a skin and hand micro-emulsion disinfectant solution with the granularity of 1 to 200nm is prepared from injection oil, the surfactant and natural moistening skincare components. The skin and hand micro-emulsion disinfectant solution is practical, simple, high in safety, good in stability and low in thrilling, nano-grade particles form a protection film on a disinfected part, the sterilizing efficacy is high, the added natural moistening skincare component can deeply moisten and whiten the skin, the symptoms such as dry and dry itching caused by utilizing the disinfectant solution with high ethanol content for a long time can be remarkably improved, and an effect for protecting the skin and the hands can be realized.

Description

technical field [0001] The invention relates to a no-wash antibacterial skin hand microemulsion disinfectant, in particular to a no-wash skin hand microemulsion disinfectant preparation and a preparation method thereof. The disinfectant preparation can kill intestinal pathogenic bacteria, pyogenic cocci, pathogenic yeast and common bacteria in hospital infection, has a disinfection effect on the skin, and has high moisturizing properties and reduces local allergic reactions. It belongs to the technology of pharmaceutical preparations field. Background technique [0002] With the improvement of people's living standards and the rapid improvement of residents' awareness of disinfection, the demand for disinfection products is also increasing. The skin is the first barrier between the body and the outside world. As residents enter and exit public places such as medical institutions, banks, restaurants, entertainment venues, schools, offices, etc., as well as conduct business t...

Claims

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Application Information

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IPC IPC(8): A61K31/155A61K9/107A61P17/00A61P31/04A61K31/14
Inventor 刘毅刘莉田霞李静李赛孟文琪崔文
Owner XUZHOU MEDICAL COLLEGE
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