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Application of reed rhizome extract and gingerol in preparation of attenuated synergistic medicines for cancer chemotherapy

A technology of gingerol and extract, which is applied in the field of natural pharmaceutical compositions, can solve the problems of patients interrupting treatment, strong toxic and side effects, acid-base balance disorders, etc., and achieve obvious synergistic effects, tumor inhibition, and good synergistic effects

Inactive Publication Date: 2013-08-14
岳晓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Frequent vomiting can lead to a large loss of digestive juice, water, electrolyte, and acid-base balance disorders, making the patient miserable, seriously affecting the patient's quality of life, not only affecting the curative effect, but even making the patient unbearable and interrupting the treatment
[0003] At present, antiemetic drugs commonly used in clinic mainly include histamine, acetylcholine, dopamine receptor antagonists and cannabinoids, etc., but these drugs have poor curative effect on post-chemotherapy vomiting, and have strong toxic and side effects, so their application is greatly limited
Newer antiemetics, such as NK 1 Antagonists and 5-HT 3 Receptor antagonist drugs, although effective in antiemetic and antiemetic after chemotherapy, are expensive, have a narrow range of use, and have large toxic and side effects. Clinically, they often need to be used in combination, and there is no anticancer synergistic effect. Therefore, natural anticancer drugs are expected. Development of drugs with attenuated toxicity and enhanced efficacy for cancer

Method used

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  • Application of reed rhizome extract and gingerol in preparation of attenuated synergistic medicines for cancer chemotherapy
  • Application of reed rhizome extract and gingerol in preparation of attenuated synergistic medicines for cancer chemotherapy
  • Application of reed rhizome extract and gingerol in preparation of attenuated synergistic medicines for cancer chemotherapy

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Experimental program
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Embodiment approach

[0032] Step 1: Preparation of various extracts

[0033] (1) Preparation of Reed Root Extract

[0034] Take the reed root, dry, crush, sieving, soak in 6 times distilled water, decoct, filter, add 6 times distilled water to the medicine residue, soak, decoct, and filter in the same way. Combine the two filtrates and centrifuge at 3000 rpm for 15 minutes. The supernatant is separated, dried under reduced pressure into a dry extract, crushed, and sieved.

[0035] (2) Preparation of gingerol

[0036] Cut the ginger into thin slices, dry naturally, use a high-speed universal pulverizer to pulverize into powder, pass a 30-mesh sieve, and put the sieved fine powder into a 5000mL large grinded bottle, soak in 6 times the amount of acetone at room temperature for 72h; ℃, 40KHz ultrasonic frequency ultrasonic extraction for 15min; centrifuge to obtain the supernatant, the residue was discarded; the supernatant was filtered under reduced pressure, the filtrate was concentrated in a rotary evapo...

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Abstract

The invention relates to a natural pharmaceutical composition, a preparation method of the natural pharmaceutical composition, and an application of the natural pharmaceutical composition in preparation of attenuated synergistic medicines for cancer chemotherapy. The natural pharmaceutical composition is prepared from reed rhizome extract and gingerol according to the ratio of (3-24):1. The composition has an excellent curative effect on side effects such as vomiting and the like caused by cancer chemotherapy, and can play a role in inhibiting tumors.

Description

Technical field [0001] The present invention relates to a natural medicinal composition, more specifically to a natural medicinal composition composed of reed root extract and gingerol, a method for preparing the natural medicinal composition and the use of the natural medicinal composition Use of vomiting side effects caused by cancer chemotherapy and synergistic effect in the treatment of cancer. Background technique [0002] Cancer has become a major killer facing human beings. Although chemotherapy has certain effects, most patients will experience gastrointestinal reactions such as nausea and vomiting after chemotherapy. Frequent vomiting can lead to a large loss of digestive juices, disturbance of water, electrolyte, and acid-base balance, making the patient miserable, seriously affecting the patient's quality of life, not only affecting the curative effect, and even making the patient intolerable and interrupting the treatment. [0003] At present, the commonly used antieme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/48A61P35/00A61P1/08A61K31/12
Inventor 岳晓
Owner 岳晓
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