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Application of aspongopus total alkaloids in preparation of medicines or health care products with antibacterial, anti-inflammatory, antipyretic and immunological enhancement functions

A technology of total alkaloids and immune promotion, applied in antibacterial drugs, application, antipyretics and other directions, to achieve the effect of improving market value, broadening application scope and controlling quality

Inactive Publication Date: 2014-08-20
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no report about the biological activity of the total alkaloids

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  • Application of aspongopus total alkaloids in preparation of medicines or health care products with antibacterial, anti-inflammatory, antipyretic and immunological enhancement functions
  • Application of aspongopus total alkaloids in preparation of medicines or health care products with antibacterial, anti-inflammatory, antipyretic and immunological enhancement functions
  • Application of aspongopus total alkaloids in preparation of medicines or health care products with antibacterial, anti-inflammatory, antipyretic and immunological enhancement functions

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Embodiment Construction

[0011] specific implementation

[0012] In order to make the purpose, technical scheme and advantages of the present invention clearer, the pharmacological action and effect of the total alkaloids of Nine-Scented Worm are described in detail below.

[0013] 1. Preparation of the total alkaloids of Nine Fragrance

[0014] Weigh 2 kg of Jiuxiangworm medicinal material, add 10 times the amount of water and decoct twice, each decoction for 1 hour, filter the decoction, combine the filtrate, centrifuge, take the supernatant and put it on a macroporous adsorption resin D101 column (weak pole Tianjin Haiguang Chemical Co., Ltd.), first wash with 0.2% sodium hydroxide solution until the effluent is colorless, then wash with distilled water until the effluent is neutral, and then use 50% ethanol solution After elution, the ethanol eluate was collected, concentrated under reduced pressure, and dried to obtain 40 g of total alkaloids of N. chinensis.

[0015] Content determination meth...

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Abstract

The invention discloses application of aspongopus total alkaloids in preparation of medicines or health care products with antibacterial, anti-inflammatory, antipyretic and immunological enhancement functions. The biological activity detection result of the aspongopus total alkaloids proves that the aspongopus total alkaloids have the inhibition effects of different degrees on diplococcus pneumoniae, staphylococcus aureus, type A streptococcus pyogens, type B streptococcus pyogens and proteusbacillus vulgaris, have obvious inhibition effects on the diplococcus pneumoniae and staphylococcus aureus, have the obvious anti-inflammatory effect on ear swell of mice caused by dimethylbenzene and have the obvious antipyretic effect on exothermic reaction of rats caused by dried yeasts, the phagocytic function of the reticuloendothelial system of the mice can be obviously enhanced, and the aspongopus total alkaloids have the immunological enhancement function and are low in toxicity and safe to use.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new application of total alkaloids of chrysanthemum chrysalis in the field of preparation of medicines and health care products. Background technique [0002] The use of antibiotics has effectively controlled many serious bacterial infectious diseases in humans, but the irrational use of antibiotics has also led to the increase of drug-resistant strains and reduced the antibacterial efficiency of existing antibiotics. Therefore, reducing the generation of drug-resistant strains and developing new antibacterial drugs has become an important topic in the medical field in the 21st century. Traditional Chinese medicine has made great contributions to the health of Chinese people for thousands of years, and has also played an active role in modern prevention and control of bacterial infectious diseases. Due to the particularity of traditional Chinese medicine, bacteria are less resi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A23L1/29A61P31/04A61P29/00A61P37/04A23L33/00
Inventor 孙凤军夏培元王显凤陈剑鸿冯伟
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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