Traditional Chinese medicine composition for treating autoimmune liver disease and preparation method thereof

An autoimmune and compositional technology, which is applied in the field of liver disease treatment, can solve problems affecting the advantages of traditional Chinese medicine, and achieve clear pharmacological mechanisms, improve efficacy, and regulate immune function

Inactive Publication Date: 2013-10-23
毛德文 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there is still a lack of traditional Chinese medicine preparations for the treatme

Method used

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  • Traditional Chinese medicine composition for treating autoimmune liver disease and preparation method thereof
  • Traditional Chinese medicine composition for treating autoimmune liver disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0035] Example 1

[0036] Formula 1: Astragalus 1000g, Rhubarb 750g, Ligustrum lucidum 750g, Turmeric 750g, Gentiana serrata 750g, Caulis spatholobi 600g, Qingfengteng 600g, Rubia 500g, Weeping grass 500g, Licorice 400 grams.

[0037] Preparation method:

[0038] (1) Weigh the raw materials according to the formula;

[0039] (2) Add water to decoct the raw materials twice, each time for 2 hours, the amount of water added each time is 12 times the total amount of the raw materials, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.05 (70℃) Clear the cream and let it cool;

[0040] (3) Add ethanol to the clear paste prepared in step (2) to make it contain 60% ethanol. Stir thoroughly and let stand overnight. The precipitate is filtered off. The ethanol is recovered from the filtrate and concentrated to a relative density of 1.30 (80%). ℃) thick paste;

[0041] (4) Add an appropriate amount of dextrin to the thick paste obtained in step (3), mix well,...

Example Embodiment

[0042] Example 2

[0043] Recipe 2: Astragalus 1500g, Rhubarb 500g, Ligustrum lucidum 1500g, Turmeric 750g, Gentiana macrophylla 500g, Caulis spatholobi 1000g, Caulis lanceolata 750g, Madder 500g, Weeping grass 500g, Licorice 500 g.

[0044] The preparation method is basically the same as that in Example 1. The relative density of the clear ointment is 1.07 (70°C), and the relative density of the thick ointment is 1.30 (80°C); 1000g granules are prepared, divided into 10g (equivalent to 80g crude drug) / bag.

Example Embodiment

[0045] Example 3

[0046] Recipe 3: 1000 g Astragalus, 1000 g Rhubarb, 750 g Ligustrum lucidum, 1500 g Turmeric, 750 g Gentiana, 1500 g Caulis spatholobi, 1000 g Cyclobalanopsis vine, 1500 g madder, 500 g Weeping grass, Licorice 400 grams.

[0047] The preparation method is basically the same as that of Example 1. The relative density of clear ointment is 1.10 (70°C), and the relative density of thick ointment is 1.35 (80°C); 1000g granules are prepared, divided into 10g (equivalent to 99g crude drug) / bag.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating an autoimmune liver disease, and a preparation method thereof. The traditional Chinese medicine composition comprises the following medicinal raw materials in parts by weight: 15-30 parts of astragalus membranaceus, 10-30 parts of cooked rhubarb, 10-30 parts of glossy privet fruit, 10-30 parts of radix curcumae, 10-30 parts of large-leaved gentian, 10-30 parts of caulis spatholobi, 10-30 parts of caulis sinomenii, 10-30 parts of radix rubiae, 10-30 parts of sedum sarmentosum and 5-15 parts of liquorice. The traditional Chinese medicine has the effects of strengthening body resistance, detoxifying, dispersing stagnated liver qi for promoting bile flow, promoting blood circulation to remove blood stasis, expelling wind and removing dampness; the main treatment range comprises autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and overlap syndrome of any two in the three diseases; and the traditional Chinese medicine composition has the treatment effects of restoring immune balance, inhibiting liver inflammation, protecting liver function, resisting hepatic fibrosis, improving clinical symptoms, improving survival quality and the like, and has high safety.

Description

technical field [0001] The invention belongs to the technical field of liver disease treatment, and in particular relates to a traditional Chinese medicine composition for treating autoimmune liver disease and a preparation method thereof. Background technique [0002] Autoimmune liver diseases (AILD) are a group of autoimmune-mediated hepatobiliary system damage diseases, mainly including autoimmune hepatitis (autoimmune hepatitis, AIH), primary biliary cirrhosis (primary biliary cirrhosis) , PBC), primary sclerosing cholangitis (Primary sclerosing cholangitis, PSC), and overlap syndromes of any two of these three diseases. AILD is an idiopathic disease involving the liver parenchyma due to the immune dysfunction of the body. The onset is insidious, recurrent, protracted and difficult to heal, and eventually dies due to liver cirrhosis and liver failure. Due to environmental pollution, drugs, virus infection and other factors, the incidence of AILD in my country is increas...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/16A61P37/02
Inventor 毛德文邱华
Owner 毛德文
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