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Anthricin preparation method

A technology of ginseng lactone and acetaminophen, applied in the field of biotechnology chemistry, can solve the problems of low sample yield, complicated operation, small preparation amount and the like

Inactive Publication Date: 2013-12-04
NANJING BIAOKE BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complicated operation, small amount of preparation and low sample yield, it is difficult to realize industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 10kg of ginseng and grind it, add 5 times the amount of 70% ethanol solution, reflux extraction 3 times, combine the extracts to shrink to no alcohol, add to AB-8 macroporous resin for adsorption, first elute with 8 times the column volume of 30% ethanol, and then Elute with 7 times the column volume of 75% ethanol solution, collect the eluent, concentrate under reduced pressure, add an equal volume of benzene solution to the concentrated solution and stir thoroughly, collect the benzene solution layer and concentrate it to a small volume and place it for crystallization. The obtained crystals were dissolved in 10 times the amount of 80% methanol, added activated carbon to decolorize, the filtrate was concentrated to an alcohol concentration of 30%, and then extracted twice with benzene solution, the extract was added to 1 / 3 ethanol solution and placed for recrystallization, and the crystallized product obtained 3.5 g of ginseng lactone , detected by HPLC, the conte...

Embodiment 2

[0016] Take 10kg of ginseng and grind it, add 10 times the amount of 30% ethanol solution, reflux extraction twice, combine the extracts to shrink to no alcohol, add to D101 macroporous resin for adsorption, first elute with 5 times the column volume of 20% ethanol, and then use 10 The column volume was eluted with 70% ethanol solution, the eluate was collected, concentrated under reduced pressure, an equal volume of benzene solution was added to the concentrated solution and stirred thoroughly, the collected benzene solution layer was concentrated to a small volume and left to crystallize. The obtained crystals were dissolved in 5 times the amount of 90% methanol, added activated carbon to decolorize, the filtrate was concentrated to an alcohol concentration of 50%, and then extracted twice with benzene solution, the extract was added to 1 / 10 ethanol solution and placed for recrystallization, and the crystallized product obtained 3.1 g of ginseng lactone , detected by HPL...

Embodiment 3

[0018] Take 10kg of ginseng and grind it, add 10 times the amount of 90% ethanol solution, reflux extraction twice, combine the extracts to shrink to no alcohol, add an appropriate amount of water solution, then add HZ816 macroporous resin for adsorption, first wash with 5 times the column volume of 50% ethanol Then eluted with 10 times the column volume of 75% ethanol solution, collected the eluate, concentrated under reduced pressure, added an equal volume of benzene solution to the concentrated solution and stirred thoroughly, collected the benzene solution layer and concentrated it to a small volume and placed it for crystallization. The obtained crystals were dissolved in 8 times the amount of 80% methanol, added activated carbon to decolorize, the filtrate was concentrated to an alcohol concentration of 40%, and then extracted twice with benzene solution, and the extract was added to 1 / 5 ethanol solution and left to recrystallize, and the crystals obtained 3.9 g of gi...

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Abstract

The invention discloses an anthricin preparation method. The method includes the following steps: 1), taking anthricin for smashing, adding 5-10 times of amount of 30-90% ethanol solution, performing reflux extraction for 2-3 times, concentrating an extracting solution to be alcohol-free, adding the extraction solution in macroporous resin for adsorption, using ethanol solution for gradient elution, collecting eluent, depressurizing for concentration, adding benzene solution in size volume and fully stirring, collecting a benzene solution layer to be concentrated to a small size, and placing for crystallization; 2), dissolving obtained crystals by 5-10 times of amount of 80-90% methanol, adding activated carbon for decoloring, concentrating filtrate to enable alcohol concentration to be 30-50%, extracting by benzene solution, adding 1 / 3-1 / 10 ethanol solution in extract liquor, placing for recrystallizing, and drying crystal substances to obtain anthricin. The anthricin preparation method is simple and convenient in process operation, low in production cost and easy to realize industrial production.

Description

technical field [0001] The invention belongs to the field of biotechnology chemistry, and in particular relates to a preparation method of ashen lactone. Background technique [0002] Ashen lactone is a lignin substance, CAS number 24150-39-8, molecule is C22H22O7, molecular weight 398.4, colorless columnar crystal, melting point 166-169, has liver protection, anti-virus, anti-tumor effects. [0003] Ashen is the root of Umbelliferae, which can invigorate the middle and replenish qi, remove blood stasis and generate new energy. Root: used for bruises, low back pain, cough due to lung deficiency, cough and hemoptysis, abdominal distension due to spleen deficiency, weakness of limbs, frequent urination in the elderly, edema; leaves: externally used to treat wounds. Modern studies have found that Aspen contains a large amount of lignin substances, such as Ashen lactone, iso-Assen lactone, etc. [0004] Through literature search, the existing preparation method of ashen lacton...

Claims

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Application Information

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IPC IPC(8): C07D493/04
Inventor 张金芳万冬梅
Owner NANJING BIAOKE BIO TECH
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