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Traditional Chinese medicinal preparation for treating infantile acute suppurative otitis media and preparation method thereof

A technology for suppurative otitis media and traditional Chinese medicine preparations is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery, which can solve the problems of short Eustachian tube, toxic and side effects, and poor curative effect, and achieve exact curative effect, toxicity and toxicity. Effects with few side effects

Inactive Publication Date: 2013-12-11
刘琳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. In children, the Eustachian tube is short, the isthmus is wide, the lumen is relatively large, and the position of the pharynx is relatively low. Microorganisms such as internal secretions and bacteria can easily invade the middle ear through this
[0005] 2. Children have low body resistance and are prone to various upper respiratory infectious diseases, such as measles, scarlet fever, whooping cough, etc.
[0007] 4. The local immune function of the middle ear of children is not fully developed, and the defense ability is poor
[0014] Most of the medicines for treating acute suppurative otitis media in the prior art are treated with western medicine. Although there are some curative effects, the curative effect is not good enough, there are certain toxic and side effects, and it is easy to relapse

Method used

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preparation example Construction

[0045] Wherein, when the dosage form of described Chinese medicine preparation is syrup, its preparation method comprises the following steps:

[0046] In the first step, the cowsage, physalis, lime and bitter leaves are mixed according to the stated ratio, dissolved in ethanol with an alcohol concentration of 80% to 90% relative to 3 to 5 times the mass of the obtained mixture, and heated to reflux for 2 After ~4 hours, extract and filter to obtain the first filtrate; dissolve the filter residue again with ethanol with an alcohol concentration of 90% to 95% relative to the mass of the obtained mixture, heat and reflux for 2 to 3 hours and then extract. Filtrate to obtain the second filtrate; combine the first filtrate and the second filtrate, recover ethanol under reduced pressure and concentrate until the concentration of the drug solution is 0.7-0.9g crude drug / mL, and use a macroporous adsorption resin column with a volume of 5L to elute , first eluted with deionized water...

Embodiment 1

[0053] The syrup preparation that embodiment 1 present invention prepares

[0054] Take 340g of cow ear grass, 170g of physalis, 350g of lime, 180g of bitter leaves, 100g of achyranthes, 260g of usnea, 190g of bamboo shoots, 150g of nobile strands, 230g of calendula, 210g of gentian and 170g of mountain bean leaves;

[0055] Its preparation method comprises the following steps:

[0056] In the first step, mix the cowsage, physalis, limes and bitter leaves according to the stated ratio, dissolve them in ethanol with an alcohol concentration of 90% which is 3 times the mass of the obtained mixture, heat and reflux for 2 hours, extract, and filter , to obtain the first filtrate; the filter residue is dissolved again with 95% ethanol of 3 times the alcohol concentration relative to the obtained mixture quality, extract after heating and reflux for 2 hours, filter to obtain the second filtrate; combine the first filtrate and For the second filtrate, ethanol is recovered under redu...

Embodiment 2

[0060] Embodiment 2 The drops prepared by the present invention

[0061] Take 320g of cow ear grass, 190g of physalis, 370g of lime, 150g of bitter leaves, 110g of achyranthes, 290g of usnea, 160g of bamboo shoots, 170g of nobile strands, 210g of calendula, 230g of gentian and 190g of mountain bean leaves;

[0062] Its preparation method comprises the following steps:

[0063] The raw medicinal material is soaked in 85% ethanol with 5 times the concentration for 35 hours, and then heat-extracted at 80°C for 3 times, each time for 2 hours, to obtain an ethanol extract; finally it is concentrated to 40°C with a relative density of 1.06 Concentrate.

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PUM

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Abstract

The invention discloses a traditional Chinese medicinal preparation for treating infantile acute suppurative otitis media and a preparation method thereof. The traditional Chinese medicinal preparation comprises the following medicinal raw materials: boea hygrometrica, wintercherry, pothos chinensis, torenia vagans roxb, local achyranthes aspera, Chinese usnea, giant reed shoot, honeysuckle stem, calendula, conyza blinii and caudate sweetleaf leaf. The traditional Chinese medicinal preparation has the beneficial effects of clearing heat, removing toxicity, dispelling wind, eliminating dampness, activating blood circulation to remove stasis, reducing swelling and draining pus on the basis of the traditional Chinese medical theory, has definite curative effect on infantile acute suppurative otitis media and hardly causes toxic and side effects.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine preparation for treating acute suppurative otitis media in children and a preparation method thereof. Background technique [0002] Acute suppurative otitis media is acute suppurative inflammation of the middle ear mucosa caused by bacterial infection. The disease is more common in children. Clinically, it is characterized by otalgia, ear discharge, tympanic membrane congestion, and perforation. If the treatment is timely and appropriate, the drainage of secretions is smooth, and the perforation of the tympanic membrane can heal itself after the inflammation subsides, and the hearing can mostly return to normal. Improper treatment or serious condition may leave tympanic membrane perforation, middle ear adhesions, tympanosclerosis or turn into chronic suppurative otitis media, and even cause var...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/08A61P27/16
Inventor 刘琳吕咸进王永萍管丽王玉云
Owner 刘琳
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