Application of rhynchophylline in preparation of drug with anxiolytic effect and antidepressant effect

A rhynchophylline and anti-anxiety technology, which is applied in the direction of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve the problems of anti-anxiety and anti-depressant preparations without rhynchophylline on the market, so as to broaden the scope of disease prevention and treatment, non-toxic Side effects, clear effects

Active Publication Date: 2013-12-18
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no literature report on rhynchophylline for anti-anxiety and anti-depression, and

Method used

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  • Application of rhynchophylline in preparation of drug with anxiolytic effect and antidepressant effect
  • Application of rhynchophylline in preparation of drug with anxiolytic effect and antidepressant effect
  • Application of rhynchophylline in preparation of drug with anxiolytic effect and antidepressant effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Preparation of rhynchophylline capsules

[0086] A Chinese herbal medicine, which is a medicament made from rhynchophylline, an effective monomer component of traditional Chinese medicine, and is used for preventing and treating anxiety and depression.

[0087] Prescription: Rhynchophylline (active ingredient) 50g, lactose (excipient) 80g, starch (excipient) 70g, magnesium stearate (anti-adhesive agent) 2.5g, made into 1000 capsules in total.

[0088] Preparation method: pass the active ingredients and pharmaceutical excipients through a 100-mesh sieve, weigh them accurately according to the prescription, mix them in a mixer for 10-15 minutes, add 2.5 g of magnesium stearate, mix them for 2 minutes, and put them into 1000 capsules. have to. Each capsule contains 50mg of rhynchophylline.

[0089] Dosage: Take orally, 1 capsule each time, 2-3 times a day.

Embodiment 2

[0091] Preparation of Rhynchophylline Soft Capsules

[0092] A Chinese herbal medicine, which is a medicament made from rhynchophylline, an effective monomer component of traditional Chinese medicine, and is used for preventing and treating anxiety and depression.

[0093] Prescription: Rhynchophylline (active ingredient) 50g, vegetable oil (excipient) 70g, beeswax (excipient) 30g, methyl p-hydroxybenzoate (preservative) 1g, make 1000 soft capsules altogether.

[0094] Preparation method: pass the active ingredient through a 100-mesh sieve, accurately weigh the main drug and auxiliary materials according to the prescription of the preparation, place them in colloidal grinding to form an oily paste suspension, and make 1000 soft capsules. Each capsule contains 50mg of rhynchophylline.

[0095] Dosage: Take orally, 1 capsule each time, 2-3 times a day.

Embodiment 3

[0097] Preparation of rhynchophylline granules

[0098] A Chinese herbal medicine, which is a medicament made from rhynchophylline, an effective monomer component of traditional Chinese medicine, and is used for preventing and treating anxiety and depression.

[0099] Formula: Rhynchophylline (active ingredient) 250g, dextrin (excipient) 100g, stevia (flavoring agent) in an appropriate amount.

[0100] Preparation method: Pass the active ingredients and pharmaceutical excipients through a 100-mesh sieve, weigh them accurately according to the prescription, mix them evenly in a mixer, granulate them by dry method, and pack them. Each contains rhynchophylline 30mg.

[0101] Dosage: Take orally, 1 pack at a time, 3-4 times a day.

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PUM

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Abstract

The invention relates to a drug of indole alkaloid, and particularly relates to application of rhynchophylline in preparation of adrug with an anxiolytic effect and an antidepressant effect. The drug disclosed by the invention is composed of the rhynchophylline and pharmaceutical acceptable auxiliary materials, wherein the content of the rhynchophylline is 1-99.5%. The drug disclosed by the invention is oral preparations and can be tablets, capsules or the like.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to rhynchophylline used to prepare a series of anti-anxiety and anti-depression drugs for mental disorders. Background technique [0002] Mental disorders, also known as mental illnesses, refer to abnormalities in perception, thinking, emotion, behavior, volition, intelligence, and other psychomotor aspects caused by brain dysfunction under the influence of biological, social, and psychological factors. With the development of society, people pay more and more attention to mental disorders. Among the 10 diseases that cause the heaviest burden on society, mental diseases account for 4 of them. Psychiatry is gradually attracting the attention of medical colleagues and society and has been given a new understanding. Anxiety disorder is a common type of mental disorder, and the application of anti-anxiety drugs is the main method for treating anxiety disorders. Anxiety disorder is a ne...

Claims

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Application Information

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IPC IPC(8): A61K31/438A61P25/22A61P25/24
Inventor 周吉银周世文莫志贤汤建林徐颖
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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