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New application of compound traditional Chinese medicine composition

A use and technology of yam, applied in the field of traditional Chinese medicine compound pharmaceutical composition, can solve the problems of affecting stem cell differentiation, affecting mesenchymal hepatocyte proteoglycan gene expression and the like

Active Publication Date: 2013-12-18
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To sum up, the traditional Chinese medicine compound Zuogui pill can promote the proliferation of embryonic stem cells and mesenchymal stem cells, and affect the gene expression of collagen and proteoglycan in mesenchymal hepatocytes. There is no report about its effect on stem cell differentiation

Method used

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  • New application of compound traditional Chinese medicine composition
  • New application of compound traditional Chinese medicine composition
  • New application of compound traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 The preparation of medicine of the present invention

[0033] Weigh raw materials: Rehmannia glutinosa 24g, dogwood 12g, yam 12g, medlar 12g, dodder 12g, antler gum 12g;

[0034]Preparation method: The above six flavors, except the antler gum, the other six flavors such as Rehmannia glutinosa are crushed into fine powder, sieved and mixed. Take the deer horn gelatin, mix it with the above fine powder, dry and seal it for storage, and take it with water, or add 10g of refined honey and an appropriate amount of water for every 100g of powder.

Embodiment 2

[0035] Embodiment 2 The preparation of medicine of the present invention

[0036] Weigh raw materials: Rehmannia glutinosa 24g, dogwood 9g, yam 12g, medlar 9g, dodder 12g, antler gum 12g;

[0037] Prepared according to the method of Example 1.

Embodiment 3

[0038] Embodiment 3 The preparation of medicine of the present invention

[0039] Weigh raw materials: Rehmannia glutinosa 18g, dogwood 9g, yam 8g, medlar 9g, dodder 8g, antler glue 8g; prepared according to the method in Example 1.

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Abstract

The invention discloses application of a compound traditional Chinese medicine composition to preparation of an inducing solution for directionally differentiating first trimester-derived perivascular cells as egg-like cells. The compound traditional Chinese medicine composition comprises the following bulk drugs in parts by weight: 18 to 30 parts of prepared rehmannia rhizome, 9 to 12 parts of dogwood, 8 to 16 parts of Chinese yam, 9 to 12 parts of barbary wolfberry fruit, 8 to 16 parts of south dodder seed and 8 to 16 parts of deer-horn glue. The invention also discloses the inducing solution and an inducing method for directionally differentiating the first trimester-derived perivascular cells as the egg-like cells. By virtue of the inducing solution, the first trimester-derived perivascular cells can be induced to be directionally differentiated as the egg-like cells. The inducing solution has great clinical application prospect.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine compound pharmaceutical composition, in particular to the application in preparing an induction solution for directional differentiation of stem cells around umbilical cord vessels of aborted embryos in early pregnancy into egg-like cells. Background technique [0002] In recent years, due to serious environmental pollution, increased work pressure, changes in eating habits, reproductive system diseases and other factors that adversely affect normal conception, the number of infertile patients is on the rise, with an incidence rate of about 12.5% ​​to 15%. increasing trend year by year. Therefore, the World Health Organization (WHO) announced that infertility, cardiovascular disease, and tumors are listed as the three major diseases that affect human life and health today. Since the world's first test-tube baby was born in 1978, the introduction of assisted reproductive techn...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P15/08C12N5/075A61K35/32
Inventor 陆华叶尚勉胡翔刘志斌
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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