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Mercuric sulfamonomethoxine and preparation method thereof

A technology of sulfa-metamethoxine and mercury-methoxine, which is applied in the field of sulfonamide transition metal complexes and their preparation, and can solve problems such as poor antibacterial properties

Inactive Publication Date: 2013-12-18
尹爱萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the invention is to solve the technical problem that sulfonamides have poor antibacterial properties to bacteria, and provide a kind of sulfamethoxine mercury and preparation method thereof. Bacteriostasis, and the preparation method is simple, low in cost, easy to industrialize

Method used

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  • Mercuric sulfamonomethoxine and preparation method thereof
  • Mercuric sulfamonomethoxine and preparation method thereof
  • Mercuric sulfamonomethoxine and preparation method thereof

Examples

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Embodiment 1

[0018] Mercury sulfamethoxine in the present embodiment, it is that 2:1 chemical synthesis is made by sulfamethoxine and mercuric chloride by the amount ratio of substance, and the structural formula of mercury sulfamethoxine is:

[0019]

[0020] The molecular formula is: C 22 h 22 N 8 o 6 S 2 Hg.

[0021] The preparation method of above-mentioned mercuric sulfamethoxine, its preparation steps are: 1. take by weighing raw material sulfamethoxine 2.90g and mercuric chloride 1.40g; 2. be that 10% NaOH solution is put into reaction vessel by 10g concentration, Then add 2.90g of sulfamethoxine into the container, stir magnetically, and react at room temperature for 5h; ③ Dissolve 1.40g of mercuric chloride in twice distilled water to make a concentration of 0.255mol L -1 mercuric chloride aqueous solution; ④ place the reaction vessel in a water bath at 60°C, continue to stir, slowly and uniformly add the mercuric chloride aqueous solution into the reaction vessel, keep it...

Embodiment 2

[0023] Mercury sulfamethoxine in this embodiment is the same as mercury sulfamethoxine in Example 1.

[0024] The preparation method of above-mentioned mercuric sulfamethoxine, its preparation steps are: 1. take by weighing raw material sulfamethoxine 3.48g and mercury chloride 1.69g; 2. be that 10% NaOH solution is put into reaction vessel by 10g concentration, Then add 3.48g of sulfamethoxine into the container, stir magnetically, and react at room temperature for 5h; ③ Dissolve 1.69g of mercuric chloride in twice distilled water to make a concentration of 0.255mol L -1 mercuric chloride aqueous solution; ④ place the reaction vessel in a water bath at 60°C, continue to stir, slowly and uniformly add the mercuric chloride aqueous solution into the reaction vessel, keep it warm for 5 hours, and generate a large amount of off-white precipitate, which is the wet product of sulfamethoxine mercury ; 5. the sulfa-methoxine mercury wet product generated by the reaction is filtered u...

Embodiment 3

[0026] Mercury sulfamethoxine in this embodiment is the same as mercury sulfamethoxine in Example 1.

[0027] The preparation method of above-mentioned mercury sulfamethoxine, its preparation steps are: 1. take by weighing raw material sulfamethoxine 4.26g and mercury chloride 2.06g; 2. be that 10% NaOH solution is put into reaction vessel by 10g concentration, Then add 4.26g of sulfamethoxine into the container, stir magnetically, and react at room temperature for 5h; ③ Dissolve 2.06g of mercuric chloride in double distilled water to make a concentration of 0.255mol L -1 mercuric chloride aqueous solution; ④ place the reaction vessel in a water bath at 60°C, continue to stir, slowly and uniformly add the mercuric chloride aqueous solution into the reaction vessel, keep it warm for 5 hours, and generate a large amount of off-white precipitate, which is the wet product of sulfamethoxine mercury ; 5. the sulfa-methoxine mercury wet product generated by the reaction is filtered u...

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Abstract

The invention belongs to sulfonamide transition metal compounds and preparation methods thereof, and specifically relates to mercuric sulfamonomethoxine and a preparation method thereof. The invention mainly solves the technical problem that sulfonamide medicines are poor in antibacterial activity. The technical scheme adopted by the invention is as follows: mercuric sulfamonomethoxine is prepared by synthesizing sulfamonomethoxine and mercuric chloride in ratio of amount of substance of: 2:1. The preparation method comprises the following steps: (1) weighing raw materials according to the ratio of amount of substance of: 2:1 of sulfamonomethoxine toand mercuric chloride; (2) sequentially adding NaOH liquor and sulfamonomethoxine into a container according to the mass ratio of sulfamonomethoxine toand 10% NaOH liquor of (2.9-5.6):10, and stirring to react for 5 hours at normal temperature; (3) preparingproportioning mercuric chloride into 0.255mol / L<-1> mercuric chloride aqueous liquor; (4) adding the mercuric chloride aqueous liquor into the container at 60 DEG C, and insulating to react for 5 hours to generate a mercuric sulfamonomethoxine wet product; (5) decompressing and filtering the produced wet product, washing the product with redistilled water and absolute ethyl alcohol, and vacuum-drying the product at 40 DEG C for 12 hours to obtain the mercuric sulfamonomethoxine product.

Description

technical field [0001] The invention belongs to sulfonamide transition metal complexes and a preparation method thereof, in particular to mercury sulfa-metamethoxine and a preparation method thereof. Background technique [0002] Sulfamethoxine is a kind of sulfonamide drugs, which can hinder the synthesis of folic acid in bacteria, so as to achieve the effect of antibacterial, which belongs to the sulfonamide antibacterial drugs. However, in recent years, the resistance of bacteria to sulfonamides has increased. For example, in the treatment of scalds and burns, sulfonamides cannot effectively prevent the infection of bacteria in scalds and burns. Contents of the invention [0003] The object of the invention is to solve the technical problem that sulfonamides have poor antibacterial properties to bacteria, and provide a kind of sulfamethoxine mercury and preparation method thereof. Antibacterial properties, simple preparation method, low cost and easy industrialization....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/47A61P31/04
Inventor 尹爱萍伊秀娟
Owner 尹爱萍
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