Preparation method of fungal extract for inhibiting human immunodeficiency virus

A technology of extracts and fungi, applied in the field of preparation of endophytic fungi extracts, can solve problems such as environmental pollution and destruction, depletion of plant resources, etc.
CN103451234AInactive Publication Date: 2013-12-18INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
Publication Date
2013-12-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of a fungal extract for inhibiting human immunodeficiency virus (HIV-1). The dependent bacterial strain is hypoxylon fungi Q-s-4(hypoxylon sp.). The fungi Q-s-4 is fermented and cultured in liquid to prepare extract of fermentation products. The method can be applied to the mass industrial culture of fungi Q-s-4 and industrial production of extract of fermentation products by taking fermentation products as the raw materials. The extract prepared by the method has a prominent activity on inhibiting HIV-1 integrase, an antibacterial activity, and an important value on research and development of novel drugs for curing AIDS and bacterial infections.
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Description

technical field

[0001] The invention belongs to the technical field of bioengineering, and in particular relates to a preparation technology of an endophytic fungus extract capable of inhibiting the expression of human immunodeficiency virus (HIV-1) integrase. technical background

[0002] Acquired immunodeficiency syndrome (AIDs) is caused by infection with human immunodeficiency virus (HIV). Since it was first reported by the Centers for Disease Control and Prevention in the United States in 1981, it has become one of the leading causes of death in the world. As of 2007, about 33.4 million people were infected with HIV worldwide, of which 22.4 million lived in sub-Saharan Africa, and about two-thirds of the population was infected with HIV. By the end of 2010, some 6.6 million people in low- and middle-income countries worldwide had received antiretroviral drug treatment, an almost 22-fold increase since 2001. Nearly 30 anti-HIV-1 drugs currently in clinical use, supplem...

Claims

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