Gamithromycin injection and preparation method thereof

A gamimycin and injection technology, which is applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of high irritation at the injection site, high production cost, complicated process, etc. problem, to achieve the effect of remarkable effect, stable property and simple process
CN103462884AActive Publication Date: 2013-12-25TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
TIANJIN ZHONGSHENG TIAOZHAN BIOTECH
Publication Date
2013-12-25

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Abstract

The invention discloses a gamithromycin injection and a preparation method thereof. The gamithromycin injection is prepared from the components including gamithromycin, a cosolvent, an antioxidant and water for injection, and is characterized by comprising 5-35 g of gamithromycin, 1-15 ml of the cosolvent, 0.1-0.5 g of the antioxidant and the balance of water for injection in every 100 ml injection. The preparation method comprises the steps as follows: dissolving the cosolvent in the water for injection, continuously adding gamithromycin and stirring to enable the gamithromycin to be dissolved, then adding the antioxidant to adjust pH to be 4.0-6.0, filtering and sterilizing, so that the gamithromycin injection is obtained. The gamithromycin injection is stable in properties, fast in absorption, remarkable in effect and simple in the preparation method, has less irritation to an injection part, effectively solves the problem that the gamithromycin is indissolvable in water, and meets the requirement of mass industrial production.
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Description

technical field

[0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a gamimycin injection and a preparation method thereof. Background technique

[0002] Gamithromycin (Gamithromycin), trade name Zactran, belongs to the macrolide antibiotics, mainly used in the treatment of cattle infections caused by bacterial pathogens such as Pasteurella hemolytica, Pasteurella multocida and histophilia disease, has the advantages of fast absorption, wide distribution in the body, low residual in the body, and high safety, and has no adverse reaction reports, and has broad application prospects in veterinary clinics. It is produced by the French Merial Company. A preparation method of garamimycin, which is insoluble in water, and currently approved to use glycerin as a solvent injection (containing 150mg / mL garamimycin), that is, using glycerin as a solvent and succinic acid as a cosolvent, Thioglycerol is used as ...

Claims

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