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Traditional Chinese medicine for resisting mycobacterium trberculosis and preparation method thereof

An anti-tuberculosis and traditional Chinese medicine technology, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, and medical preparations containing active ingredients, etc. , to achieve strong anti-tuberculosis effect and strong resistance to drug resistance

Active Publication Date: 2014-01-01
JIUZHITANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently widely used anti-tuberculosis drugs are isoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin, rifapentine, etc. Patients develop drug resistance and drug resistance due to long treatment time , and there are side effects of damage to the liver, kidney, etc. For the treatment of extrapulmonary tuberculosis (such as bone tuberculosis, tuberculous meningitis), chemotherapy or surgery is usually used. to suffer physically and mentally
At present, there is no report on the anti-tuberculosis effect of Zizhu nudiflora in vitro and in vivo

Method used

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  • Traditional Chinese medicine for resisting mycobacterium trberculosis and preparation method thereof
  • Traditional Chinese medicine for resisting mycobacterium trberculosis and preparation method thereof
  • Traditional Chinese medicine for resisting mycobacterium trberculosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Injection

[0054] prescription:

[0055]Nadihua Zizhu (fresh, leaves and twigs, dry rate 33.2%) 500g sodium chloride 7g Tween-80 5g add water for injection to 1000ml

[0056] Preparation method:

[0057] Add 1.5 times the amount of water to break into a homogenate, squeeze, filter, concentrate the squeezed liquid to a relative density of 1.03~1.10 (60°C), add ethanol until the alcohol content reaches 50%, stir, refrigerate, precipitate, Filtrate, recover ethanol from the filtrate, concentrate to 500ml, add ethanol until the alcohol content reaches 80%, refrigerate for 24 hours, filter, recover ethanol from the filtrate until it has no alcohol smell, combine with the distillate, filter, add sodium chloride, Tween-80, stir to dissolve, add water for injection to 1000ml, use G 3 Filter through a vertically fused glass funnel and sterilize.

Embodiment 2

[0058] Example 2 Aerosol

[0059] prescription:

[0060] Naked flower purple pearl 800g (fresh, leaves and twigs, dry rate 33.2%) appropriate amount of difluorodichloromethane appropriate amount of ethanol

[0061] Preparation method:

[0062] Add 0.5 times the amount of water to crush the naked flower purple pearl into a homogenate, squeeze and filter to obtain the squeezed liquid, add 1 times the amount of 50% ethanol to the remaining squeezed residue to extract once, filter after extraction, get the filtrate, and combine the filtrate and the squeezed liquid , concentrated to a relative density of 1.15~1.35 (60°C), combined with the squeezed liquid, added ethanol until the alcohol content reached 75%, precipitated, filtered, recovered the ethanol from the filtrate until it had no alcohol smell, added distilled water to 1000ml, mixed well, filtered After that, pack it in an aerosol pressure-resistant container and press into difluorodichloromethane to obtain it.

Embodiment 3

[0063] Example 3 Spray

[0064] prescription:

[0065] Naked flower purple pearl 1000g (fresh, leaves and twigs, dry rate 33.2%) Paraben 0.25 g

[0066] Preparation method:

[0067] Add 3 times of water to break into a homogenate, squeeze, filter, and concentrate the squeezed liquid to a clear paste with a relative density of 1.03~1.06 (60°C), and add 5 times the amount of 90% ethanol to extract the remaining squeezed residue once , extract and filter to obtain the filtrate, concentrate the filtrate to a clear paste with a relative density of 1.03~1.06 (60°C), combine it with the clear paste obtained from the squeezed liquid, add paraben, dissolve, filter, add distilled water to 1000ml, and pack In the sprayer, that is.

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PUM

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Abstract

The invention provides a traditional Chinese medicine prepared from callicarpa nudiflora. The traditional Chinese medicine has an effect of resisting mycobacterium trberculosis. At the same time, a preparation method of the traditional Chinese medicine is also disclosed.

Description

technical field [0001] The invention relates to an anti-tuberculosis medicine, in particular to an anti-tuberculosis traditional Chinese medicine and a preparation method thereof. Background technique [0002] Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis can affect multiple organs throughout the body, but pulmonary tuberculosis is the most common. Currently widely used anti-tuberculosis drugs are isoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin, rifapentine, etc. Patients develop drug resistance and drug resistance due to long treatment time , and there are side effects of damage to the liver, kidney, etc. For the treatment of extrapulmonary tuberculosis (such as bone tuberculosis, tuberculous meningitis), chemotherapy or surgery is usually used. Come physically and mentally. In order to overcome the above problems, the invention provides a traditional Chinese medicine with short medication time, low cost and high cu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P31/06
Inventor 冯星黄胜李伟袁莉周覃刘翀谷陟欣陈珍贵
Owner JIUZHITANG
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