Artificial dura mater spinalis, and preparation method and use method thereof

A dural, artificial technology, applied in the field of biomedicine, can solve problems such as epidural scarring, and achieve the effect of easy operation and strong operability

Inactive Publication Date: 2014-01-01
于凤宾 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide an artificial dura mater, which is

Method used

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  • Artificial dura mater spinalis, and preparation method and use method thereof
  • Artificial dura mater spinalis, and preparation method and use method thereof
  • Artificial dura mater spinalis, and preparation method and use method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] refer to figure 1 , Preparation of oriented polylactic acid / glycolic acid copolymer nanofiber membrane:

[0045] Weigh polylactic acid / glycolic acid copolymer according to the formula (the ratio of lactic acid to glycolic acid is 80:20, the molecular weight is 100,000, purchased from Shandong Jinan Daigang Biomaterials Co., Ltd.), and the volume ratio of the preparation is 1 :1 THF and DMF mixed solution, dissolve the polylactic acid / glycolic acid copolymer with the above 5mL mixed solution to make a polylactic acid / glycolic acid copolymer solution with a solute mass and solution volume ratio of 1:5, stir for a day and night as spinning liquid. The prepared spinning solution is put into the syringe 6, the positive electrode 3 of the high voltage power supply 1 is connected to the spinning solution, the negative electrode 2 of the high voltage power supply 1 is connected to the receiving plate 4, and the spinning voltage is stabilized at 13-15kV. The distance between t...

Embodiment 2

[0050] Embodiment 2: Prepare orientation and non-orientation polylactic acid / glycolic acid copolymer nanofiber film, adopt the ratio of the amount of substance of lactic acid and lactic acid and glycolic acid to be 70:30, the molecular weight is the copolymer of 80000, other Operation is with embodiment 1.

Embodiment 3

[0051] Embodiment 3: preparation has orientation and non-orientation polylactic acid / glycolic acid copolymer nanofiber film, adopts the copolymer that the ratio of the amount of substance of lactic acid and lactic acid and glycolic acid is 85:15, molecular weight is 120000, the rest Operation is with embodiment 1.

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Abstract

The invention provides an artificial dura mater spinalis, and a preparation method and a use method thereof. The artificial dura mater spinalis has a double-layer structure and concretely comprises an internal layer and an external layer, the internal layer is an oriented polylactic acid/glycollic acid copolymer nanofiber membrane, the external layer is a non-oriented polylactic acid/glycollic acid copolymer-chitosan nanofiber membrane, and the internal layer and the external layer are connected. The invention belongs to the technical field of the biomedicine. The artificial dura mater spinalis can realize the dura mater spinalis regeneration and prevent epidural scarring and adhesion, and can substantially reduce the postoperative cerebrospinal leakage incidence rate.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an artificial dura mater and its preparation method and application method. Background technique [0002] Dural injury is common in spinal surgery and neurosurgery. Trauma, tumor resection in the spinal canal, dural dysplasia, dural ossification, and surgery involving the spinal canal can all cause rupture or defect of the spinal canal, leading to cerebrospinal fluid extravasation. Improper treatment can cause cerebrospinal fluid leakage, low Many serious complications such as intracranial pressure syndrome, acute airway obstruction, cerebrospinal fluid cyst, adhesive arachnoiditis, spinal canal infection, and intracranial infection can even be life-threatening. In addition, for operations involving lamina fenestration or resection and decompression that may result in postoperative dura exposure, postoperative epidural scar formation will lead to epidural adhesio...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61F2/44
Inventor 于凤宾岑莲陈德玉李强廖心远
Owner 于凤宾
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