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Traditional Chinese medicine composition containing fatty acid and preparation method of composition

A fatty acid and composition technology, applied in the field of traditional Chinese medicine, can solve problems such as stimulation of gastric mucosa, long course of treatment, damage to liver and kidney functions, and achieve controllable quality and good curative effect

Inactive Publication Date: 2014-01-15
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since coronary heart disease is a chronic disease, the course of drug treatment is long, and long-term use of drugs can cause serious adverse reactions such as headache, cough, stimulation of gastric mucosa, hypotension, inhibition of heart function, and damage to liver and kidney functions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Extract danshen with water twice, add 6 times the amount of water for the first time, keep the temperature at 90°C for 1.5 hours, and filter; add 4 times the amount of water for the second time, keep the temperature at 90°C for 0.5 hours, filter, and combine the filtrates; Pore ​​resin adsorption, elution with water, 20% ethanol for the first time, and 60% ethanol for the second time, collect the eluate; steam pressure 0.01Mpa, vacuum degree -0.03Mpa, temperature 60°C, concentrate to a relative density of 1.20 g / cm 3 Extract (measured at 50-55°C); vacuum degree -0.04Mpa, temperature 60°C, dry, crush and pass through a 60-mesh sieve to obtain.

[0081] After testing, the content of tanshinone in the salvia miltiorrhiza extract is 58.03%.

[0082] Weigh by weight 8% of Salvia miltiorrhiza extract; 10% of eicosapentaenoic acid, 26% of docosahexaenoic acid; 56% of garlic oil, and add auxiliary materials to prepare the traditional Chinese medicine composition of the present...

Embodiment 2

[0084] Extract danshen with water twice, add 10 times the amount of water for the first time, keep the temperature at 100°C for 3 hours, and filter; add 8 times the amount of water for the second time, keep the temperature at 100°C for 1.5 hours, filter, and combine the filtrates; Pore ​​resin adsorption, elution with water, 60% ethanol for the first time, 95% ethanol for the second time, collect the eluate; steam pressure 0.09Mpa, vacuum degree -0.08Mpa, temperature 80°C, concentrated to a relative density of 1.25 g / cm 3 Extract (measured at 50-55°C); vacuum degree -0.09Mpa, temperature 95°C, dry, crush and pass through a 60-mesh sieve to obtain.

[0085] After testing, the tanshinone content in the salvia miltiorrhiza extract is 77.62%.

[0086] Weigh 36% of Salvia miltiorrhiza extract by weight; 12% of eicosapentaenoic acid; 52% of garlic oil, and add auxiliary materials to prepare the traditional Chinese medicine composition of the present invention.

Embodiment 3

[0088] Extract danshen with water twice, add 10 times the amount of water for the first time, keep the temperature at 100°C for 1.5 hours, and filter; add 6 times the amount of water for the second time, keep the temperature at 100°C for 1.5 hours, filter, and combine the filtrates; Pore ​​resin adsorption, elution with water, 30% ethanol for the first time, 70% ethanol for the second time, collect the eluate; steam pressure 0.04Mpa, vacuum degree -0.04Mpa, temperature 65°C, concentrated to a relative density of 1.20 g / cm3 extract (measured at 50-55°C); vacuum degree -0.04Mpa, temperature 60°C, dried, crushed through a 60-mesh sieve, and obtained.

[0089] After testing, the content of tanshinone in the salvia miltiorrhiza extract is 62.71%.

[0090] Weighing 12% of Salvia miltiorrhiza extract; 38% of docosahexaenoic acid; 50% of garlic oil, and adding auxiliary materials to prepare the traditional Chinese medicine composition of the present invention.

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Abstract

The invention discloses a traditional Chinese medicine composition containing fatty acid. The composition comprises the following components by weight percent: 8-36% of salvia extract, 12-64% of fatty acid and 6-56% of garlic oil. The invention also discloses a preparation method of the traditional Chinese medicine composition. The preparation method comprises the steps of extracting active ingredients and preparing the finished product according to the formula. The traditional Chinese medicine composition makes the best of the treatment effects of active pharmaceutical ingredients on cardiovascular diseases, adopts scientific matching, generates synergistic effects, has better curative effects and more controllable quality than traditional preparations and is suitable for industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] With the continuous improvement of people's living standards, changes in diet structure, population aging is becoming more and more obvious, and the incidence of coronary heart disease is increasing day by day. Coronary heart disease is a heart disease caused by narrowing of the lumen caused by coronary atherosclerosis, which causes myocardial blood supply and oxygen supply disturbance, and is known as the "world killer". As far as the whole world is concerned, coronary heart disease has become one of the most serious diseases threatening human health in the past half century, and it is the main cause of death in the United States and some industrialized countries. According to the statistics of the World Health Organization, 24....

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61K36/9066A61P9/00A61P9/10A61K31/20
Inventor 崔卜东贾林
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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