Mesoporous bioactive glass-modified porous ceramic ball prosthetic eye holder and preparation method thereof
A technology of porous ceramic balls and bioglass, which is applied in the field of medical biomaterials, can solve the problems of strict sterilization and transportation conditions, high price, and short half-life, and achieve the effects of rapid vascularization, low cost, and reduced cutting and processing.
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Embodiment 1
[0039] 1) Slowly add 0.3 mol / L calcium nitrate aqueous solution dropwise to mechanically stirred equal-volume 0.18 mol / L ammonium phosphate aqueous solution, stabilize the pH of the ammonium phosphate solution at 10.5 with ammonia water, and continue stirring for 12 hours after the dropwise addition is completed, The reaction precipitate was filtered, washed twice with deionized water and absolute ethanol, dried, and washed at 900 o C Calcination treatment for 2 hours to obtain nHA powder with a particle size of 20-500 nm.
[0040] 2) Using monodisperse paraffin microspheres with a diameter of 500 μm as a pore-forming agent, they were tightly packed in a spherical filter funnel with an inner diameter of 12 mm to form a porous template. o Cool to room temperature after standing for 2 minutes under C, then the nHA synthesized in step 1) is made into a slurry with a solidified mass ratio of 12% by a 3% PVA aqueous solution with a mass ratio and added dropwise to the above porous ...
Embodiment 2
[0043] The preparation method is the same as in Example 1, the difference is that the calcium acetate in step 3) is replaced by calcium nitrate, and the molar ratio of silicon, calcium, phosphorus and copper is changed to 80:10:10:0; the nHA prepared in step 2) is The porous ceramic balls were placed in the gel, impregnated with negative pressure suction, and allowed to stand for 15 minutes, then the nHA porous spheres were taken out, and the excess gel in the pores was sucked out by vacuum filtration for 5 minutes, and dried at room temperature. This process was repeated twice to obtain a thicker mesoporous bioglass coating; the result was a copper-free mesoporous bioglass modified porous ceramic spherical prosthetic eye socket (control group), denoted as 0Cu-MBG-HA.
Embodiment 3
[0045] The preparation method is the same as in Example 1, the difference is that the nHA porous ceramic balls prepared in step 2) are placed in the gel, impregnated with negative pressure suction, and left to stand for 15 minutes, then the nHA porous balls are taken out, vacuum filtered for 5 minutes to suck out The excess gel in the channel is dried at room temperature. This process was repeated twice to obtain a thicker mesoporous bioglass coating, figure 2 Showing the microscopic topography of this embodiment enlarged by 50 times, 1 is a porous channel, and 2 is a through hole; image 3 Middle 3 is the mesoporous bioglass on the channel wall of the prosthetic eye seat. The obtained prosthetic eye seat was recorded as 2Cu-MBG-HA.
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