Preparing method of compound brucea javanicaseed oil liposome freeze-dried powder

A technology of oil liposome and javanica javanica oil, which is applied in the direction of liposome delivery, freeze-drying delivery, and medical preparations containing active ingredients, etc., which can solve the problems of multi-drug resistance, large amount of chemotherapy drugs, toxic and side effects, etc.

Inactive Publication Date: 2014-02-26
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Problems solved by technology

However, the curative effect of chemotherapy has always been at a low level. The reason is that the amount of chemotherapy drugs is large, most of which lack specific pharmacological activity, have extensive and strong cytotoxicity, and have serious side effects on cancer tissues and normal tissues. Prone to allergic reactions and multidrug resistance during medication

Method used

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Embodiment 1

[0029] The preparation method of compound brucea javanica oil liposome freeze-dried powder is characterized in that comprising the following steps:

[0030]1) Weigh 30g of soybean lecithin, 6g of cholesterol, 2g of vitamin E, and 4g of javanica javanica oil, and dissolve them in ethanol to 200mL as the oil phase;

[0031] The javanica javanica oil is prepared by the following method: pulverize the medicinal material of javanica javanica through a 18-mesh sieve, add petroleum ether for cold soaking and extract 2 times, extract 8 hours each time, the consumption of petroleum ether is 12 times of the weight of the medicinal material of javanica javanica, and roughly extract The Brucea javanica oil was fed with nitrogen, heated at 110°C for 2h to remove residual petroleum ether, then added active carbon of 5% by weight of the Brucea javanica medicinal material and heated at 110°C for 1h, and decolorized to obtain Brucea javanica oil;

[0032] 2) Take 1000mL water extract of toadst...

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Abstract

The invention provides a preparing method of a compound brucea javanicaseed oil liposome freeze-dried powder, and belongs to the technical field of traditional Chinese medicine preparation. The preparing method is characterized by comprising the following steps: 1) weighing soybean phospholipids, cholesterol, vitamin E and brucea javanicaseed oil, dissolving by ethanol, and taking as an oil phase; 2) measuring a toad venom aqueous extract, adding mannitol and sucrose, and adding distilled water to as an aqueous phase; 3) injecting the oil phase into the aqueous phase, and extruding by a micropore filter membrane to obtain a suspension; 4) filling a penicillin bottle with the suspension, carrying out freeze drying, and thus obtaining the compound brucea javanicaseed oil liposome freeze-dried powder. The preparation method of the compound brucea javanicaseed oil liposome freeze-dried powder adopts the brucea javanicaseed oil and toad venom for combined application, the average encapsulation rate of the prepared liposome freeze-dried powder is 91.90%, the average content of indole alkaloids is 5.19*10<-3> mg.g<-1>, the average content of oleic acid is 79.08 mg.g<-1>, the average content of linoleic acid is 50.41 mg.g<-1>, the antitumor effect is good, and toxic and side effects are small.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of compound brucea javanica oil liposome freeze-dried powder. Background technique [0002] With the change of economy and life structure, the morbidity and mortality of cancer have been continuously rising. Therefore, the research and development of anticancer drugs has become an urgent worldwide issue. Modern medicine has developed rapidly in the diagnosis and pathogenesis of malignant tumors, but the treatment methods have shown limitations. After more than half a century of continuous development and improvement, chemotherapy has become one of the important means of comprehensive treatment of malignant tumors. However, the curative effect of chemotherapy has always been at a low level. The reason is that the amount of chemotherapy drugs is large, most of which lack specific pharmacological activity, have extensive an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K9/127A61K36/185A61P35/00A61K35/56A61K35/65
Inventor 黄绳武赵丹丹李雅雅蒋杉杉王俊俊李玉清
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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