The invention discloses a preparation method of small unilamellar
vesicle liposome of
ivermectin, and relates to a preparation method of
ivermectin liposome, which solves the problems that the existing
ivermectin preparation has short
effective date, and needs to deliver
drug repeatedly and the sustained release
macro-
pill of the ivermectin has high
toxicity. The method comprises the following steps of: adding raw ivermectin
powder in organic solution of
soya bean lecithin and
cholesterol, then carrying out
pressure reduction, rotation and
evaporation to the obtained
injectable suspension tilla layer of thin film is formed at the inner wall of a reactor, then dissolving the thin film in PBS solution, adding glass beads into a rotary-type oscillator, shaking to wash the film for 1 hour, then standing for 1 hour, and carrying out
ultrasonic oscillation so as to obtain the small unilamellar
vesicle liposome of ivermectin. The liposome obtained by the preparation method has similar structure as a
biofilm, can be biodegraded in the
organism, does not generate toxic substances, and can be slowly and continuously released as embedded
drug in a storage mode, thus being capable of prolonging effective horizontal period of the
drug and reducing
drug delivery frequency; and the packet rate of the small unilamellar
vesicle liposome of ivermectin is 89.5%.