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Uses of methylprednisolone and derivatives thereof in preparing medicament for treating allergic rhinitis

A technology for allergic rhinitis and methylprednisolone, which can be used in drug combination, drug delivery, and pharmaceutical formulations to solve problems such as telangiectasia, high price, and skin atrophy, so as to reduce systemic effects and avoid atrophic effects , the effect of reducing the therapeutic dose

Active Publication Date: 2010-09-22
天津药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing studies have shown that although halogen-containing glucocorticoids have strong anti-inflammatory activity, the above-mentioned halogen-containing hormones can cause local skin atrophy, telangiectasia and other problems when used externally for a long time
Moreover, due to the difficulty in the synthesis of halogen-containing corticosteroids and the high cost of raw materials, the pharmaceutical preparations for the treatment of allergic rhinitis with the above-mentioned glucocorticoids as active ingredients generally have a higher price.

Method used

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  • Uses of methylprednisolone and derivatives thereof in preparing medicament for treating allergic rhinitis
  • Uses of methylprednisolone and derivatives thereof in preparing medicament for treating allergic rhinitis
  • Uses of methylprednisolone and derivatives thereof in preparing medicament for treating allergic rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Methylprednisolone 20mg

[0056] Ephedrine Hydrochloride 0.5g

[0057] Glycerol 5ml

[0058] Carbomer 934 300mg

[0059] 5% ethylparaben ethanol solution 600μL

[0060] Get the prescribed amount of Carbomer 934 and add glycerin to wet and grind, add 50ml of purified water to swell as a gel matrix, and purify the prescribed amount of ephedrine hydrochloride, methylprednisolone, and 5% ethylparaben ethanol solution in 20ml Disperse with water, slowly add to the gel matrix and stir well, adjust the pH value to 6.0 to 7.0 with an appropriate amount of 1mol / L sodium hydroxide, and add purified water to 100ml.

Embodiment 2

[0062] The scheme described in embodiment 1, active ingredient is changed into:

[0063] Methylprednisolone Acetate 25mg

[0064] L-carbastine 20mg

[0065] The dosage of Carbomer 934 was adjusted to 200 mg, other ingredients and preparation method were the same as in Example 1, the prepared pharmaceutical composition was sub-packaged, and the nozzle was installed to obtain the nasal spray gel.

Embodiment 3

[0067] Methylprednisolone Acetone 50mg

[0068] Sodium carboxymethylcellulose 0.4g

[0069] Methylparaben 30mg

[0070] Glycerol 5ml

[0071] Take the prescribed amount of sodium carboxymethyl cellulose, add sodium chloride to 20ml of purified water, stir well and filter, add the prescribed amount of methylparaben into 50ml of purified water, heat to 70°C until completely dissolved, let cool and dissolve the two parts The solution is mixed and added with prescribed amount of methylprednisolone acetone, stirred evenly, the pH value is adjusted to 5.5 to 7.0, and the remaining water for injection is added. Get nasal drops.

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Abstract

A pharmaceutical composition for treating allergic rhinitis comprises one or a plurality of kinds from methylprednisolone taken as active ingredient or pharmaceutically acceptable salt thereof or esterified matters thereof, and a pharmaceutical composition consisting of one or a plurality of inactive ingredients applicable to local action inside nasal cavity.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for treating allergic rhinitis. Background technique: [0002] Allergic rhinitis, also known as allergic rhinitis, is an allergic disease of the nasal mucosa and can cause various complications. Allergic rhinitis can occur at any age, both men and women, and it is easy to see in young people. The main reasons are: [0003] (1) Inhalational allergens: such as indoor and outdoor dust, dust mites, fungi, animal fur, feathers, cotton wadding, etc., often cause perennial attacks; plant pollen causes mostly seasonal attacks. [0004] (2) Food allergens: such as fish and shrimp, eggs, milk, flour, peanuts, soybeans, etc. Especially certain drugs, such as sulfonamides, quinine, antibiotics, etc. can cause disease. [0005] (3) Contact objects such as cosmetics, gasoline, paint, alcohol, etc. [0006] Others may be certain bacteria and their toxins, physical factors (such as changes in cold and heat, te...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573A61K9/00A61K9/06A61K9/12A61K9/70A61K47/38A61K47/44A61P11/02A61P37/08A61K47/32
Inventor 郝于田陈松张乐杨新意
Owner 天津药业集团有限公司
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