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A kind of pharmaceutical composition containing inorganic arsenic compound and its application

A composition, inorganic arsenic technology, applied in the direction of drug combination, medical preparations containing active ingredients, inorganic active ingredients, etc., can solve problems such as insufficient activity, reduce systemic toxicity, enhance inhibitory effect, and reduce therapeutic dose. Effect

Active Publication Date: 2019-04-16
NANTONG YUFUYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More and more studies have found that scutellarin and its derivatives show good application prospects in the field of anti-tumor, but the activity is not strong enough

Method used

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  • A kind of pharmaceutical composition containing inorganic arsenic compound and its application
  • A kind of pharmaceutical composition containing inorganic arsenic compound and its application
  • A kind of pharmaceutical composition containing inorganic arsenic compound and its application

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Experimental program
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Effect test

Embodiment

[0015] Breast cancer MDA-MB-231 cells in the logarithmic growth phase were seeded in 96-well plates, 3×10 per well 3 cells. Set CO 2 Samples were added after 24 hours of incubation at 37°C in an incubator. Add 10 μL of PBS solution to the control group; add 5 μL of PBS solution and 5 μL of arsenic trioxide solution to the arsenic trioxide group; Wherein the final concentrations of scutellarin and scutellarin aglycone are respectively μmol L -1 , each group was set up with 6 multiple wells, and each experiment was repeated 3 times. Put in 37°C CO 2 in the incubator. After 48 hours, add 20 μL MTS solution, 37°C CO 2 Continue to incubate in the incubator for 2 hours, and measure the absorbance (A) at 490 nm with an automatic microplate reader. All of the above were completed under the funding of Yunnan Collaborative Innovation Center for Public Health and Disease Prevention and Control (2016YNPHXT15).

[0016] The specific result is

[0017] Table 1 Inhibitory effect of ...

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PUM

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Abstract

The invention discloses a medicine composition containing inorganic arsenic compounds and application thereof. The medicine composition comprises inorganic arsenic compounds, scutellarin or scutellarein, is used for preparing medicines for treating cancers, and has a better effect on cancer cell inhibition than that by singly using inorganic arsenic compounds and that by singly using scutellarin or scutellarein. According to the medicine composition, the treatment dosage of inorganic arsenic compounds can be reduced, the cancer inhibition effect can be enhanced, and the systematic toxin of inorganic arsenic compounds can be effectively reduced.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing an inorganic arsenic compound and its application, in particular to a pharmaceutical composition containing an inorganic arsenic compound and scutellarin or scutellarin aglycon, and its preparation for treating cancer drug application. Background technique [0002] In 1971, Han Taiyun of the First Affiliated Hospital of Harbin Medical College transformed a Chinese medicine containing arsenic into a medicine for treating leukemia. In 1973, Zhang Tingdong, Zhang Peng, etc. applied "Ailing No. 1" to treat chronic myeloid leukemia, which improved the hematological indicators and clinical symptoms of patients. It has been proved that the inorganic compound arsenic trioxide can treat relapsed or refractory acute promyelocytic leukemia (APL), and recent preliminary data show that arsenic trioxide also has an effect on other cancers, so the study of arsenic trioxide as an anticancer drug is one ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/36A61P35/00A61K31/7048A61K31/352
CPCA61K31/352A61K31/7048A61K33/36A61K2300/00
Inventor 何越峰尚莉平妮娜王立萍姚树祥张若冰
Owner NANTONG YUFUYUAN PHARMA CO LTD
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