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Liposome of astragaloside IV and its medicinal preparation

A technology of astragaloside IV and astragaloside IV, which is applied in the field of medicine, can solve the problems of increasing the psychological burden and medical burden of patients, increasing the heart burden of heart failure patients, and the fear of injection pain, so as to improve bioavailability and increase Stability in vivo and in vitro, and the effect of overcoming poor oral absorption

Inactive Publication Date: 2007-08-01
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These problems include: 1. In order to prepare injections, the dissolution of astragaloside IV must be solved, so harmful cosolvents and surfactants are used for injection. 2. Patients with chronic heart failure have a long course of disease, and most of them do not need hospitalization. Long-term infusion will increase the patient's psychological burden and medical burden. 3. Intravenous infusion of drugs generally has a large input volume, which will increase the heart burden of heart failure patients and aggravate the degree of heart failure. There is a sense of fear in the pain of injection. If the medication cycle is long, this problem will become more prominent. 5. There are unsafe factors in the injection process, such as allergic reactions, pyrogen reactions, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 1g of soybean lecithin and 0.3g of cholesterol, dissolve them in a 250ml eggplant-shaped bottle with 50ml of chloroform-methanol (2:1) mixture, then add 20ml of astragaloside IV absolute ethanol solution, mix well, and reduce The solvent was evaporated under pressure, and phosphate buffer was added for rotary hydration to obtain astragaloside IV liposomes. The encapsulation efficiency was 82%.

Embodiment 2

[0027] Take 1g of soybean lecithin and 0.3g of cholesterol, dissolve it in a 250ml eggplant-shaped bottle with 50ml of chloroform-methanol (2:1) mixture, add 1ml of astragaloside dimethylacetamide solution, mix well, and freeze in a vacuum After drying, shake with physiological saline to disperse to obtain astragaloside IV liposomes. The encapsulation efficiency was 67%.

Embodiment 3

[0029] Take 1g of soybean lecithin and 0.5g of cholesterol, dissolve it with 50ml of chloroform-methanol (2:1) mixed solution, then add 30ml of astragaloside IV absolute ethanol solution, mix well, and slowly inject the drug solution into the stirred In the phosphate buffer, after the addition, the organic solvent was removed under reduced pressure to obtain astragaloside liposomes. The encapsulation efficiency was 61%.

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Abstract

The invention relates to a astragaloside liposome and method for preparing same, wherein the liposome is prepared from astragaloside, phosphatide and lipophilic additives, the weight ratio of phosphatide and astragaloside is 0.5:1-100:1, the weight ratio of phosphatide and lipophilic additives is 1:1-50:1. The liposome can be used for preparing powdered inhalant, aerosols, sprays and oral mucosa doses.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a liposome pharmaceutical preparation, more specifically, an astragaloside IV liposome and a pharmaceutical preparation containing astragaloside IV liposome. Background technique [0002] Astragalus is one of the most commonly used traditional Chinese medicines with a long history and wide clinical application. Traditional Chinese medicine believes that astragalus is warm in nature and sweet in taste, and has the functions of invigorating qi and raising yang, solidifying the surface and antiperspirant, detoxifying and promoting muscle growth, reducing swelling and diuresis. Astragaloside IV is a monomeric compound extracted from the traditional Chinese medicine Astragalus membranaceus. In recent years, a large number of studies have shown that astragaloside IV can be used in the prevention and treatment of cardiovascular system diseases, especially in the treatment of chronic heart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/481A61K9/127A61K9/14A61K9/12A61K9/72A61P9/04
Inventor 王亚静李章才
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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