81results about How to "Avoid tolerance" patented technology

The present invention pertains to the identification of moieties and methods of using the same for preventing tolerance to bronchodilators. More specifically, the present invention pertains to the identification of compositions and methods which are capable of preventing tolerance to beta2-adrenergic agonists. The methods and compositions according to the invention are also useful as analytical tools for functional studies and as combination therapeutic tools.

The invention discloses a novel large-tonnage bridge girder erection machine and a construction method thereof. The novel large-tonnage bridge girder erection machine comprises a main frame structure composed of a bridge girder erection machine main girder, a main girder front-linkage straining beam, a main girder rear-linkage straining beam. The main frame structure is provided with a middle supporting device, a front auxiliary supporting device and a rear auxiliary supporting device which are sequentially connected. The novel construction method of the novel large-tonnage bridge girder erection machine includes a bridge girder erection machine via hole process, a via hole and girder erection conversion process, a bridge girder erection machine girder erection process, a girder erection and via hole conversion process, a normal girder erection and tail span conversion process, a variable span construction process, a small curved section construction process and a pack transferring construction process. The novel large-tonnage bridge girder erection machine achieves the purpose that a prefabricated bridge is mounted through the bridge girder erection machine under the conditions of a large span, a large tonnage, small curvature, various changes of the span and amplitude, frequent transferring and the like and has the advantages of being safe, efficient, easy to operate and maintain, good in stability, dispersed in construction load and the like.

The invention concerns a device for back injecting an implant (30) into the skin (22) of a subject, said device (1) include a hollow main body (10), to which a hollow needle (28) is fixed into which the implant (30) is introduced, a secondary body (12; 114) coaxially arranged inside the main body (10) and surrounding the needle (28) and a piston rod (88) able to slide coaxially inside said hollow needle (28) and whose position relative to said needle (28) remains unchanged when the back injection device (1) is pressed against the subject's skin (22) to allow the needle (28) to penetrate said subject's skin and when the secondary body (12) retracts inside the main body (10), the piston rod (88) penetrating the interior of the hollow needle (28) to hold the implant (30) at the required depth in the subject's skin (22) during withdrawal of the hollow needle (28) from the subject's skin (22), during which the secondary body (12; 114) exits the main body (10), characterized in that it includes means for the elastic return of the secondary body (12) from the main body (10).

Methods of the prophylaxis of the development of allergy in a patient at risk of sensitization to an antigen(s) or allergen(s) due to impaired gastrointestinal functions include administering a mast cell inhibitor, e.g., ketotifen, e.g., ketotifen fumarate. Methods for prophylactically treating, reducing, delaying or controlling gastrointestinal disorders include administering a mast cell stabilizer, e.g., ketotifen to a patient in need thereof. Pharmaceutical preparation, composition for use in methods described, are also disclosed. Also disclosed are methods of prophylaxis or treating gastrointestinal and esophageal inflammation, and methods for the prophylaxis of the development of additional allergies to a newly introduced substance in a patient with a preexisting allergy. Such methods include delivery of a mast cell stabilizer, e.g., ketotifen. Oral and topical administration are contemplated within the scope of the methods.

A rivet setting machine is provided. In another aspect, a linear displacement sensor directly senses and detects a position of a rivet-setting punch relative to a nosepiece of a rivet setting machine. A further aspect provides a control system and software instructions for sensing the relative position of a punch and nosepiece used by a programmable controller to determine and monitor a rivet setting position without use of a force sensor, motor current/voltage sensor, or a rotation sensor.

A hinge device capable of locking a buffer switch position comprises a movable hinge cup and a hinge joint arm, wherein the movable hinge cup and the hinge joint arm are in hinge joint connection. A buffer mechanism is arranged on the movable hinge cup, the hinge joint arm at least acts on the buffer mechanism when a hinge is closed, the buffer mechanism comprises a damper and a gland, the damper is arranged in a concave position of the movable hinge cup, the gland is arranged on the damper, and the damper can slide back and forth on the gland. A damp switch component is arranged on the gland in a rotating or swing mode, and the limiting and/or restoration of a buffering stroke of the damper are/is achieved by rotating or swinging the damp switch component when the hinge is opened and/or closed. The gland and/or the damp switch component are/is made of plastic having certain elasticity, a limiting part is arranged between the gland and the damp switch component, and the damp switch component achieves position locking and the limiting and /or the restoration of the buffering stroke of the damper through the limiting part. The hinge device capable of locking the buffer switch position has the advantages of being simple and reasonable in structure, reliable in performance, long in service life, low in manufacturing cost, fast and convenient to adjust and accurate and firm in locating.

A method of producing holes in a component, in particular of turbomachines, wherein each hole extends from a first, outer surface to a second, inner surface of the component and wherein the method has, for example, the following steps: producing a 3D model of the actual geometry of the component, at least for the region of the holes; adopting each hole on the basis of the actual geometry of the component; generating a production program for each individual hole. In this way, the process quality and with it the quality of the holes increases, because the offset of holes caused by component tolerances is avoided and the drilling funnels are formed according to specification. Furthermore, drilling defects on account of the offset of holes and/or cores can be avoided. Overlapping holes caused by component tolerances are likewise avoided.

A fine adjustment mechanism includes a connecting unit and a fine-tuning bolt having a bolt shaft and a bolt head. The bolt shaft has a threaded section rotatably engaged with the connecting unit, a non-threaded section between the threaded section and the bolt head, and an annular protrusion projecting outwardly and radially from an outer surface of the non-threaded section and spaced apart from the bolt head. A retaining unit is molded over the fine-tuning bolt and covers the annular protrusion and portions of the non-threaded section which are proximate to two opposite annular end surfaces of the annular protrusion. The fine-tuning bolt is rotatable relative to the retaining unit. The connecting unit is movable along the threaded section when the fine-tuning bolt is rotated.

In a method of operating an exhaust emission control device, the presence of an actual pressure loss of a particulate filter is determined, and a model pressure loss is determined as a function of a state variable. On the basis of the actual pressure loss and the model pressure loss a pressure quotient is determined and a condition of the particulate filter is ascertained in a diagnostic mode in response to the pressure quotient.

The present invention relates to the use of Ca²⁺/CaM-dependent protein kinase II (CaMKII) inhibitors alone and in combination with opiate analgesics for treating pain, in particular chronic pain. Methods for reducing or reversing tolerance, dependence, and opioid-induced hyperalgesia are also provided.

Neurological disorders and diseases, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and Down's syndrome, can be ameliorated or beneficially treated by administration of a formulation comprising an effective amount of a pyrone-indole derivative of formula (I)

Ar—B—Ar′  (I)

wherein AR represents an indole nucleus ring system:

Ar′ represents an alpha-, beta- or gamma-pyrone nucleus ring system:

and each of B, R₁, R₂, R₃, R₄, R₁′ and R₂′ are as defined herein.

An improved autovaccination method designed to prevent or treat various neoplastic diseases by inducing a systemic immune response against a tumor and its remote metastases, consisting of the induction of an immunogenic cell death in one or more targeted tumor sites with local radiation therapy, cryotherapy, heat, chemotherapy or various other treatments, followed by intratumoral/peritumoral injection of dsRNAs (poly-ICLC in particular) in the same tumor site.

A linear motion module comprises a linear rail, a sliding block and balls. The sliding block is slidingly disposed on the linear rail and comprises a sliding block body, circulation elements and end caps. The inside of the sliding block body is configured with inner circulation grooves, the inner circulation groove and the rail groove constitute an inner circulation passage, and each of two sides of the sliding block body is configured with at least a circulation channel that corresponds to the inner circulation passage and penetrates through the sliding block body. Each of the circulation elements includes at least a circulation tube, and the opposite two circulation tubes are connected to each other to constitute an outer circulation passage. Each of the end caps is configured with at least two circulation guiding grooves, and the circulation guiding groove is connected to the inner and outer circulation passages.

The disclosed invention generally relates to pharmaceutical and nutraceutical compounds and methods for reducing neuropathic pain and depression caused by toxicity, metabolism abnormality, trauma, compression, autoimmune abnormality, congenital/hereditary abnormality, infection, abnormally activated neuronal circuits, emotional stress, chemical imbalance, mental health disorder, or other causes in subjects in need thereof. The disclosed invention further relates to naturally occurring, synthetic and semi-synthetic multifunctional compounds that exhibit antidepressant and analgesic activity where said compound contains a pharmacologically inactive substance.

The present invention relates to novel pyrone-indole derivatives, pharmaceutical formulations containing them, and use of the compounds in the manufacture of Medicaments for treating or preventing various diseases.

The present invention relates to a pharmaceutical composition comprising a peptide of 5 to 50 amino acids which comprises the amino acid sequence NPFPTX₁X₂KRX₃X₄ (SEQ ID NO: 2) wherein X₁, X₂, X₃, and X₄ may be the same or different and each is an amino acid residue, wherein said composition is in a form suitable for a transbuccal administration and use thereof for preventing or treating pain.