Eye drops containing hyaluronic acid or its salts and propylene glycol

A technology of hyaluronic acid and sodium hyaluronate, which is applied to medical preparations containing active ingredients, medical preparations with non-active ingredients, organic active ingredients, etc. It can solve the problems of no record and insufficient preservation effect
CN103608000BActive Publication Date: 2016-05-11SANTEN PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SANTEN PHARMA CO LTD
Publication Date
2016-05-11

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Abstract

The present invention relates to an eye drop, which is an aqueous eye drop containing hyaluronic acid or its salt at a concentration of 0.03 to 0.5% (w / v) and propylene glycol at a concentration of 0.1 to 1.0% (w / v), Wherein, the eye drops contain benzalkonium chloride at a concentration of 0.001 to 0.002% (w / v) as the only preservative, and contain ionic acid, etc. penetrating agent.
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Description

technical field

[0001] The present invention relates to an aqueous eye drop containing hyaluronic acid or its salt at a concentration of 0.03 to 0.5% (w / v) and propylene glycol at a concentration of 0.1 to 1.0% (w / v). The eye drop contains 0.001 Benzalkonium chloride is used as the only preservative at a concentration of ~0.002% (w / v), and an ionic isotonizing agent is contained at a concentration that makes the osmotic pressure ratio of the eye drops 0.9-1.1. In addition, the present invention also relates to a method for improving the preservation efficacy of eye drops containing sodium hyaluronate at a concentration of 0.1 or 0.3% (w / v) and containing benzalkonium chloride as the sole preservative, and This method makes the kinematic viscosity of the eye drops reach 3.0-4.0 or 17-30mm 2 / s, and prevent dripping of the eye drops, the method includes: sodium hyaluronate in an amount of 0.1 or 0.3% (w / v) in the eye drops, the eye drops Benzalkonium chloride in an amount of 0...

Claims

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