siRNA molecule composition, and applications thereof in treatment of hypertrophic scars
A technology of hypertrophic scar and composition, which is applied in the fields of molecular biology and gene therapy to achieve good therapeutic effect and the effect of promoting apoptosis of hypertrophic scar fibroblasts
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[0046] Example 1
[0047] 1 Experimental materials
[0048] 1.1 siRNA active ingredients
[0049] TGF-β1 siRNA molecule: sense strand: 5'-ccccggaggugauuuccaucuacaa-3', antisense strand: 5'-uuguagauggaaaucaccuccgggg-3';
[0050] COX-2 siRNA molecule: sense strand: 5'-gucuuuggucuggugccuggucuga-3', antisense strand: 5'-ucagaccaggcaccagaccaaagac-3';
[0051] Drug carrier: peptide (HKP), polymer of histidine and lysine;
[0052] STP705 (siRNA cocktail): The above-mentioned TGF-β1 siRNA molecules, COX-2 siRNA molecules and HKP are formed into nanoparticles, in which the copy number ratio of TGF-β1 siRNA molecules and COX-2 siRNA molecules is 1:1. The weight ratio of HKP is 1:4. During treatment, siRNA concentration of 20μg / ml was injected into local lesions.
[0053] The above drugs are provided by Suzhou Shengnuo Biological Co., Ltd.
[0054] 1.2 Antibodies
[0055] Rabbit anti-human alpha smooth muscle Actin (α-SMA, alpha smooth muscle Actin) monoclonal antibody (ab5694, Abcam, Iowa, USA), pr...
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