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Cross-modal application of combination signatures indicative of a phenotype

A composite label and modality technology, applied in special data processing applications, genomics, proteomics, etc., can solve problems such as unavailable measurement devices

Active Publication Date: 2014-04-09
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, expensive and bulky measuring devices such as MRI devices are usually not available when the measurements described above should be made
This means that the most reliable combination of measurement modalities cannot always be combined by the examining physician

Method used

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  • Cross-modal application of combination signatures indicative of a phenotype
  • Cross-modal application of combination signatures indicative of a phenotype
  • Cross-modal application of combination signatures indicative of a phenotype

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Embodiment Construction

[0058] In general, a compound tag consists of information of data type A and data type B. These data types have been selected and optimized (a from A i and b from B j ) to allow classification into different phenotypes. Afterwards, this compound tag can be expressed as S=1 …a q ,b 1 …b k >. If data type B needs to be converted into a measured modality of data type C, the following measures can be applied. Doing so requires two key steps. First, a subset of B-type features can be selected between modality B and modality C. Subsequently, a transformation T can be applied to this subset or to the modified labels, where A-type features are represented by a subset of C-type features: S'=1 …c r > or S'=1 …a q ,c 1 …c r >. That is, the data of type A are kept constant during execution of the method according to the exemplary embodiment of the present invention. One of the interesting cases is when C=B, that is, we will get the strongest features from the data type B inpu...

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Abstract

The present invention relates to a method of adapting a composite signature of a phenotype. The method comprises the steps of providing for a composite signature of a phenotype with at least two different data types, which were respectively generated by two different modalities of measuring a specimen. Due to an adaption of one part of the signature of the phenotype the resulting adapted phenotype signature can be used as an input for a signature evaluation tool that was derived from data measured by a third modality of measurement.

Description

technical field [0001] The present invention relates to phenotypic descriptions using multiple data types. In particular, the present invention relates to a method of modulating a phenotypic composite signature, a program element for modulating a phenotypic composite signature, and a computer-readable medium storing the program element. Background technique [0002] The advent of new measurement techniques and a deeper understanding of biology and pathogenesis have brought new approaches to better partition patient samples into phenomes. In addition to advances in the clinicopathological assessment of biological tissues, in recent years high-throughput molecular profiling techniques have provided a unique understanding of the underlying molecules and biological processes in normal as well as diseased samples. In particular, molecular profiling has enabled us to understand the processes of cancer onset and progression and possible approaches to personalize therapy primarily ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/18G16B20/20G16H10/60
CPCG06F19/18G16B20/00G16B20/20
Inventor A·亚内夫斯基S·卡玛拉卡兰N·班纳吉V·瓦拉达恩N·迪米特罗娃S·苏里亚纳拉亚南
Owner KONINKLJIJKE PHILIPS NV