A kind of hydrophobic magnetic mesoporous microsphere and its preparation method and application

A hydrophobic and magnetic technology, applied in the preparation of microspheres, the preparation of peptides, magnetic materials, etc., to achieve the effect of strong specificity, good use value, and good magnetic field sensitivity
CN103736433BInactive Publication Date: 2015-12-30FUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUZHOU UNIV
Publication Date
2015-12-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is a preparation area for organic-inorganic composite nanomaterials, which involves a hydrophobic magnetic medium microsphere and its preparation methods and applications.The process of hydrophilic magnetic medium micro-ball preparation process is as follows: (1) The solid-gel response is used as a structural guides with surfactants, and the order of the hydrophobic group with a hydrophobic group is covered with the surface of the magnetic inorganic nanoparticlesThe composite material of the silica / surfactant; (2) then remove the surface active agent through solvent extraction to obtain hydrophilic magnetic melody microspheres.The hydrophobic magnetic medium microspheres made by the present invention have a good nuclear-shell appearance, good magnetic field sensitivity, strong specificity, and good use value and potential application prospects in protein groups and other fields.
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Description

technical field

[0001] The invention belongs to the field of preparation of organic-inorganic composite materials, and in particular relates to a hydrophobic magnetic mesoporous microsphere and its preparation method and application. Background technique

[0002] In recent years, with the development of mass spectrometry bioinformatics, it has been found that endogenous peptides contain biomarkers that may record human physiological and pathological states, and these markers may have higher clinical sensitivity and higher clinical sensitivity than conventional markers. Specificity, it is expected to be used in the early diagnosis of major diseases such as cancer. However, an important problem faced by this research is that the presence of a large number of high-abundance biomacromolecules (such as proteins, etc.) in complex biological fluids (including blood, lymph, and interstitial fluid) can cause entrainment and inclusion of low-abundance endogenous peptides. It is diffi...

Claims

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