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A kind of hydrophobic magnetic mesoporous microsphere and its preparation method and application

A hydrophobic and magnetic technology, applied in the preparation of microspheres, the preparation of peptides, magnetic materials, etc., to achieve the effect of strong specificity, good use value, and good magnetic field sensitivity

Inactive Publication Date: 2015-12-30
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few reports on hydrophobic magnetic mesoporous composite materials for the separation and enrichment of peptides

Method used

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  • A kind of hydrophobic magnetic mesoporous microsphere and its preparation method and application
  • A kind of hydrophobic magnetic mesoporous microsphere and its preparation method and application
  • A kind of hydrophobic magnetic mesoporous microsphere and its preparation method and application

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Embodiment 1

[0031] Synthesis of magnetic inorganic nanoparticles by hydrothermal method: using 10.81 g of FeCl 3 ·6H 2 O, add 13.12 grams of sodium acetate as a dispersant, mix in 200 mL of ethylene glycol solution, add 2.058 grams of trisodium citrate dihydrate, then move the solution into a closed heating container, and carry out solvothermal reaction at 200 ° C , heated for 12 hours to obtain ferroferromagnetic inorganic nanoparticles; after the product was washed, it was vacuum-dried at 60° C. for 12 hours.

[0032] Preparation of magnetic mesoporous microsphere nanoparticles: Mix ferroferric oxide magnetic inorganic nanoparticles with CTAB at a ratio of 1mg / 10mg, dissolve in 50mL aqueous solution, ultrasonicate, slowly add 30mL ethanol, ultrasonicate until no bubbles are generated, add 24 μL of phenyltriethoxysilane and 96 μL of n-silane tetraethyl ester were vigorously stirred at 45°C, then 2 mL of ammonia water was added, and reacted for 6 hours to obtain template-containing hydro...

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Abstract

The present invention is a preparation area for organic-inorganic composite nanomaterials, which involves a hydrophobic magnetic medium microsphere and its preparation methods and applications.The process of hydrophilic magnetic medium micro-ball preparation process is as follows: (1) The solid-gel response is used as a structural guides with surfactants, and the order of the hydrophobic group with a hydrophobic group is covered with the surface of the magnetic inorganic nanoparticlesThe composite material of the silica / surfactant; (2) then remove the surface active agent through solvent extraction to obtain hydrophilic magnetic melody microspheres.The hydrophobic magnetic medium microspheres made by the present invention have a good nuclear-shell appearance, good magnetic field sensitivity, strong specificity, and good use value and potential application prospects in protein groups and other fields.

Description

technical field [0001] The invention belongs to the field of preparation of organic-inorganic composite materials, and in particular relates to a hydrophobic magnetic mesoporous microsphere and its preparation method and application. Background technique [0002] In recent years, with the development of mass spectrometry bioinformatics, it has been found that endogenous peptides contain biomarkers that may record human physiological and pathological states, and these markers may have higher clinical sensitivity and higher clinical sensitivity than conventional markers. Specificity, it is expected to be used in the early diagnosis of major diseases such as cancer. However, an important problem faced by this research is that the presence of a large number of high-abundance biomacromolecules (such as proteins, etc.) in complex biological fluids (including blood, lymph, and interstitial fluid) can cause entrainment and inclusion of low-abundance endogenous peptides. It is diffi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02H01F1/00C07K1/14
Inventor 林子俺王岭李诗华郑江南林津津赵森张兰杨黄浩
Owner FUZHOU UNIV
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