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Hydrophobic magnetic mesoporous microsphere as well as preparation method and application thereof

A hydrophobic and magnetic technology, used in the preparation of microspheres, the preparation of peptides, magnetic materials, etc.

Inactive Publication Date: 2014-04-23
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few reports on hydrophobic magnetic mesoporous composite materials for the separation and enrichment of peptides

Method used

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  • Hydrophobic magnetic mesoporous microsphere as well as preparation method and application thereof
  • Hydrophobic magnetic mesoporous microsphere as well as preparation method and application thereof
  • Hydrophobic magnetic mesoporous microsphere as well as preparation method and application thereof

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Embodiment 1

[0032] Hydrothermal Synthesis of Magnetic Inorganic Nanoparticles: Using 10.81 g of FeCl 3 ·6H 2 O, add 13.12 grams of sodium acetate as a dispersant, mix in 200 mL of ethylene glycol solution, add 2.058 grams of trisodium citrate dihydrate, then move the solution into a closed heating container, and carry out solvothermal heating at 200 °C The reaction was heated for 12 h to obtain ferroferromagnetic inorganic nanoparticles; the product was washed and dried in vacuum at 60 °C for 12 h.

[0033] Preparation of magnetic mesoporous microsphere nanoparticles: Mix ferroferric oxide magnetic inorganic nanoparticles with CTAB at a ratio of 1 mg / 10 mg, dissolve in 50 mL of aqueous solution, sonicate, slowly add 30 mL of ethanol, and sonicate until there are no bubbles To generate, add 24 μL phenyltriethoxysilane and 96 μL n-silane tetraethyl ester, stir vigorously at 45 °C, then add 2 mL ammonia water, and react for 6 hours to obtain template-containing hydrophobic magnetic mesoporo...

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Abstract

The invention belongs to the preparation field of organic-inorganic composite nanometer materials, in particular relates to a hydrophobic magnetic mesoporous microsphere as well as a preparation method and application thereof. The preparation process of the hydrophobic magnetic mesoporous microsphere is as follows: (1) with a surface active agent as a structure-directing agent, silicon dioxide / surface active agent composite materials, doped with hydrophobic groups and having ordered mesoporous structures, are coated on the surfaces of magnetic inorganic nanometer particles through the sol-gel reaction; (2) the surface active agent is removed through the solvent extraction to obtain the hydrophobic magnetic mesoporous microsphere. The prepared hydrophobic magnetic mesoporous microsphere has excellent nuclear-shell morphology, good magnetic field inductivity and strong specificity, and has excellent use value and potential application foreground in such fields as proteomics.

Description

technical field [0001] The invention belongs to the field of preparation of organic-inorganic composite materials, and in particular relates to a hydrophobic magnetic mesoporous microsphere and its preparation method and application. Background technique [0002] In recent years, with the development of mass spectrometry bioinformatics, it has been found that endogenous peptides contain biomarkers that may record human physiological and pathological states, and these markers may have higher clinical sensitivity and higher clinical sensitivity than conventional markers. Specificity, it is expected to be used in the early diagnosis of major diseases such as cancer. However, an important problem faced by this research is that the presence of a large number of high-abundance biomacromolecules (such as proteins, etc.) in complex biological fluids (including blood, lymph, and interstitial fluid) can cause entrainment and inclusion of low-abundance endogenous peptides. It is diffi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02H01F1/00C07K1/14
Inventor 林子俺王岭李诗华郑江南林津津赵森张兰杨黄浩
Owner FUZHOU UNIV
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