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Method for preparing technetium [99mtc] methylene bisphosphonate injection medicine with long effective period

A technology of methylene diphosphonate and stannous methylene diphosphate is applied in the field of preparation of technetium [99mTc] methylene diphosphonate injection with long validity period, and can solve problems such as waste and achieve The effect of easy transportation, stable quality and good imaging effect

Active Publication Date: 2015-10-28
SHANGHAI ATOM KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But technetium[ 99m The validity period of Tc] methylene bisphosphonate injection is only 6 hours, and there is a slight delay in transportation, and it will expire soon, causing waste

Method used

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  • Method for preparing technetium [99mtc] methylene bisphosphonate injection medicine with long effective period

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Embodiment 1

[0022] A kind of technetium [ 99m Tc] the method for methylene bisphosphonate injection drug, in the preparation technetium [ 99m After Tc] methylene bisphosphonate injection, technetium [ 99m Add vitamin C injection to Tc] methylene bisphosphonate injection. The method specifically includes the following steps:

[0023] (1) Dilute vitamin C injection to 0.005g / L-0.05g / L;

[0024] (2) extract high technetium [ 99m Sodium Tc] acid injection, the activity is 10 ~ 200mCi, and diluted to 4ml;

[0025] (3) Take out the freeze-dried product of 5 mg / bottle of stannous methylene diphosphate for injection from the refrigerator and place it at room temperature;

[0026] (4) high technetium [ 99m Sodium Tc] acid injection is injected into stannous methylene diphosphate freeze-dried product at one time, shakes, fully dissolves, and stands still for 5 minutes to obtain technetium[ 99m Tc] methylene bisphosphonate injection;

[0027] (5) Extract 0.1ml of the diluted vitamin C inject...

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Abstract

The invention relates to a method for preparing a technetium (99mTc) methylene diphosphonate injection medicament with long effective period. The method specifically comprises the following steps: diluting a vitamin C injection by 20-200 times according to the requirements; pumping 10-200mCi of high-technetium (99mTc) acid sodium injection and diluting to 4ml; taking a stannous methylene diphosphonate lyophilized product for injection out of a refrigerator and placing into room temperature; injecting the high-technetium (99mTc) acid sodium injection into the stannous methylene diphosphonate lyophilized product once, shaking, fully dissolving, standing for 5min and obtaining the technetium (99mTc) methylene diphosphonate injection; and pumping 0.1ml of the well diluted vitamin C injection by using a disposable sterile syringe, injecting into the well prepared technetium (99mTc) methylene diphosphonate injection and uniformly shaking. Compared with the prior art, the prepared technetium (99mTc) methylene diphosphonate injection medicament has the advantages of long effective period, no decomposition in transportation process, relatively good imaging effect and the like.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a method for preparing technetium with a long effective period [ 99m Tc] Methylene bisphosphonate injection drug method. Background technique [0002] Technetium [ 99m Tc] methylene bisphosphonate injection is currently recognized as an ideal bone imaging agent, which is composed of high technetium[ 99m Sodium Tc] acid and stannous methylene bisphosphonate for injection are formulated through a certain ratio. Technetium [ 99m Tc] methylene bisphosphonate injection is bound to the surface of hydroxyapatite crystals in the inorganic components of bone through chemisorption. In addition, the immature collagen in bone is also resistant to technetium[ 99m Tc] methylene bisphosphonate injection has a higher affinity. Affects the concentration of technetium in bone[ 99m The main factors of Tc] methylene bisphosphonate injection are the blood supply to the bone and the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/00A61K9/08A61K47/22A61K103/10
Inventor 陈飞
Owner SHANGHAI ATOM KEXING PHARMA
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