The invention discloses a data center liquid cooling system and relates to the technical field of data center heat dissipation devices. The system comprises a box body, a server, a cold plate, a cooling device, a liquid storage tank and a refrigerant pump. The box body is filled with a single-phase refrigerant, the server is immersed in the single-phase refrigerant, the server is connected to thebox body, the cold plate is arranged in the box body and is connected to the box body, and the cold plate is sequentially connected to the cooling device, the liquid storage tank and the refrigerant pump to form a circulation loop. The invention realizes the combination of indirect contact liquid cooling, single-phase direct immersion liquid cooling and natural cooling, so that the single-phase refrigerant does not need to be circulated under the driving of a pump but is circulated by the change of temperature and density, although the refrigerant is circulated under the driving of the refrigerant pump, the refrigerant has a smaller viscosity than that of the single-phase refrigerant and is easy to flow, the loss of the refrigerant pump is not increased, so the pump loss caused by the single-phase refrigerant is reduced, the PUE of a data center is lowered, and the greenness of the data center is improved.