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Preparation method and application of magnolia zenii bark extract

A Baohua Magnolia extract technology, applied in the field of preparation of Baohua Magnolia bark extract, can solve the problems of cumbersome operation process, achieve anti-tumor effect, simple and reasonable design effect

Inactive Publication Date: 2014-06-11
HUAIHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preparation method of the Magnoliaceae plant extract described in this scheme, there are multiple steps that require pressurization. In addition, it is necessary to consider the ternary organic solvent system as the mobile phase for elution, and the operation process is obviously cumbersome.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1, a kind of preparation method of Baohua Magnolia bark extract is characterized in that, its steps are as follows: first Baohua Magnolia bark is dried to water content lower than 10%, at room temperature with 95% of 8 times of amount Soak in industrial alcohol for a total of 3 times, the first time for 2 months, the second time for 1 month, and the third time for 20 days; combine the 3 times of leaching solution, concentrate under reduced pressure, and obtain the extract of Magnolia magnolia bark extract.

Embodiment 2

[0012] Embodiment 2, a kind of preparation method of Baohua Magnolia bark extract is characterized in that, its steps are as follows: first Baohua Magnolia bark is dried to water content lower than 10%, at room temperature with 95% of 8 times of amount Soak in industrial alcohol for a total of 3 times, the first time for 4 months, the second time for 2 months, and the third time for 40 days; combine the 3 times of leaching liquid, concentrate under reduced pressure, and obtain the extract of Magnolia magnolia bark extract.

Embodiment 3

[0013] Embodiment 3, a kind of preparation method of Baohua Magnolia bark extract is characterized in that, its steps are as follows: first Baohua Magnolia bark is dried to water content lower than 10%, at room temperature with 95% of 8 times of amount Soak in industrial alcohol for a total of 3 times, the first time for 3 months, the second time for 2 months, and the third time for 1 month; combine the 3 times of leaching solution, concentrate under reduced pressure, and obtain the extract of Magnolia magnolia bark extract. The obtained Baohua Magnolia bark extract was used as the effective part, and NF-kB and COX-2 were used as the targets to verify the anti-tumor effect of Baohua Magnolia bark extract. The bark extract of Baohua Magnolia can be used as an active ingredient to prepare anticancer drugs.

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Abstract

The invention relates to a preparation method of a magnolia zenii bark extract. The preparation method includes the following steps: drying magnolia zenii barks to the moisture content of less than 10%, soaking with 8 times the amount of a 95% industrial alcohol for 3 times at the room temperature, wherein in the first time, soaking for 2-4 months, in the second time, soaking for 1-2 months, and in the third time, soaking for 20-40 days; and merging the three leached solutions, carrying out reduced pressure concentration, and thus obtaining the magnolia zenii bark extract. The magnolia zenii bark extract can be used as an effective ingredient for preparing anti-cancer drugs. The preparation method has simple and reasonable design, and can effectively extract to obtain effective ingredients of the magnolia zenii root bark; and the obtained extract has a better anti-tumor effect.

Description

technical field [0001] The invention relates to a preparation method of a plant extract, in particular to a preparation method of Baohua magnolia bark extract. The present invention also provides the use of the extract prepared by the aforementioned method. Background technique [0002] Magnolia zenii (Magnolia zenii) is a plant of the genus Magnolia in the family Magnoliaceae, which is a unique plant in China. The aggregate fruit of Baohua Magnolia is cylindrical, 6-14 cm long, 2-3 cm in diameter, and the follicles are round, with verrucous point-like protrusions. Seeds are broadly obovate, about 1 cm in length and width, with red outer testa and black inner testa. In the prior art, the Chinese patent application with publication number CN101028341 discloses a preparation method and application of Magnoliaceae plant extract. The scheme is prepared by extracting Magnoliaceae Magnolia plants and Michelia plants by warm soaking or cold soaking or reflux, liquid-liquid extra...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61P35/00A61K129/00
Inventor 宋晓凯
Owner HUAIHAI INST OF TECH
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