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Compound composition of osthole and imazalil and its application

A technology for compounding composition and osthole, which can be used in application, biocide, animal repellent, etc., can solve the problem of drug resistance of bacteria, achieve high safety, reduce input, and reduce the toxicity of drugs. Effect

Active Publication Date: 2015-12-09
SHANDONG YANTAI AGRI SCI & TECH INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the long-term single use of imazalil in production, drug-resistant groups continue to appear, and it is easy to induce drug resistance in bacteria

Method used

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  • Compound composition of osthole and imazalil and its application
  • Compound composition of osthole and imazalil and its application
  • Compound composition of osthole and imazalil and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Indoor toxicity test and compound ratio screening

[0023] 1.1 Drugs to be tested

[0024] 94.7% osthole, provided by the Institute of Food Quality and Safety, Jiangsu Academy of Agricultural Sciences. Soluble in 95% alcohol, dubbed 10000mg / L mother liquor for later use.

[0025] 98% Imazalil original drug, provided by Yifan Biotechnology Group Co., Ltd. Dissolve it in acetone first, then make it into 10000mg / L mother liquor at constant volume for later use.

[0026] The content of manufacturers such as my country Yuancheng Technology Development Co., Ltd., Shaanxi Hebo Natural Products Co., Ltd., and Xi'an Sanwei Biotechnology Co., Ltd. is 10 to 90% of the osthole products that meet the requirements of the osthole used in the compound composition of the present invention. Requirements; and imazalil compounded with osthole is a commercially available pesticide product, as long as it meets the compounding ratio and application conditions in the present invention.

[0...

Embodiment 2

[0064] field plot experiment

[0065] According to the indoor compound ratio screening experiment, the optimal ratio of osthole:imazalil = 1:4 was selected, and we prepared a 5% osthole·imazalil composition.

[0066] 2.1 Experimental drug and community arrangement

[0067] Design 5% osthole·imazalil as a field drug against apple ring spot according to the "Guidelines for Field Efficacy Tests of Pesticides (2)" Part 118: Fungicides Control Apple Ring Spot edited by the Pesticide Control Institute of the Ministry of Agriculture effect test.

[0068] 2.1.1 Drugs to be tested

[0069] 1% osthole water emulsion 200 times, provided by Jiangsu Academy of Agricultural Sciences.

[0070] 10% Imazalil water solution 800 times, provided by Belgium Janssen Pharmaceutical Company.

[0071] 5% osthole · imazalil 400, 500, 600 times, prepared by Yantai Academy of Agricultural Sciences.

[0072] 2.1.2 Control drug

[0073] 10% difenoconazole water dispersible granules 2000 times, a prod...

Embodiment 3

[0088] safety test

[0089] The content of imazalil in the compound composition is 6 percentage points lower than that of commercially available products, so its toxicity to humans and animals and the safety to crops are in line with the requirements; the content of osthole in the compound composition is 1%. The results of the toxicity test of the accreditation agency show that 1% osthole water emulsion belongs to the slightly toxic pesticide:

[0090] Rat acute oral toxicity LD50♂>5000mg / kg,♀>5000mg / kg;

[0091] Rat acute dermal toxicity LD50♂>5000mg / kg,♀>5000mg / kg;

[0092] Rabbit eye irritation score is 0 (1h), 0 (1:100) dilution after 48h, no irritation to eyes;

[0093] Rabbit eye irritation score is 0 (4h), no irritation to skin.

[0094] The present invention establishes the optimal ratio of the two pesticides for use in production through the indoor toxicity measurement and the effect of the biological source pesticide osthole and imazalil on apple ring marks after ...

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Abstract

The invention discloses application of a compound composition of cnidium lactone and imazalil in the field of agriculture and in particular relates to application research aiming at prevention and treatment of apple ring spot. The invention provides application of the compound composition of cnidium lactone and imazalil in prevention and treatment of the apple ring spot. A weight ratio of cnidium lactone to the imazalil in the compound composition is 8:1-1:32, a synergistic ratio is 1:(1-16), and an optimal ratio is 1:4. The compound composition has outstanding advantages when being applied to aspects of preventing and treating the apple ring spot.

Description

technical field [0001] The invention relates to a compound composition containing osthole, especially the compound composition of osthole and imazalil as a fungicide used in the prevention and treatment of apple ring spot, belonging to the technical field of compound composition of fungicides . Background technique [0002] The occurrence of apple ring spot is increasing and is very common in various apple producing areas in my country. Apple ring spot mainly damages branches and fruits, and can cause a large number of rotten fruits in severe cases. The disease damages the fruit from August, and continues to increase until harvesting. The fruit rot rate is generally 20-50%, and the serious one can reach 70-90%, which directly affects the economic income of fruit farmers. [0003] Chemical control is still one of the main technical measures for apple ring spot disease, but the long-term single and large-scale blind application of chemical pesticides puts apple pests under hi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/50A01P3/00A01N43/16
Inventor 王英姿李宝燕王培松刘保友栾炳辉
Owner SHANDONG YANTAI AGRI SCI & TECH INST
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