A traditional Chinese medicine composition for preventing hyperstimulation syndrome and its application

A syndrome and composition technology, applied in the field of traditional Chinese medicine compositions, can solve problems such as severe ovarian hyperstimulation syndrome that cannot be completely avoided, and achieve the effects of definite clinical efficacy, easy quality control, and no toxic and side effects

Active Publication Date: 2017-01-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it can alleviate the patient's discomfort to a certain extent, it cannot completely avoid the occurrence of severe ovarian hyperstimulation syndrome.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 Preparation of granules of the present invention

[0013] The composition of the pharmaceutical composition: Poria cocos 100g, coix seed 200g, polyporus 150g, gorgon fruit 200g, Su stem 150g, old pumpkin pedicle 100g, roasted licorice 100g.

[0014] Preparation:

[0015] (1) The above seven herbs, Poria cocos, Coix seed, Polyporus cocos, Gorgon seed, Su stem, old pumpkin stalk, Zhigancao, add 10 times the amount of 70% ethanol for reflux extraction for 1.0 hour, extract twice in total, combine the extracts, and recover ethanol . Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of the drug solution of 1.15 (measured at 60°C). The concentrated solution is prepared...

Embodiment 2

[0017] Embodiment 2 Tablet preparation of the present invention

[0018] The composition of the pharmaceutical composition: Poria cocos 100g, coix seed 200g, polyporus 150g, gorgon fruit 200g, Su stem 150g, old pumpkin pedicle 100g, roasted licorice 100g.

[0019] Preparation:

[0020] (1) The above seven herbs, Poria cocos, Coix seed, Polyporus cocos, Gorgon seed, Su stem, old pumpkin stalk, Zhigancao, add 10 times the amount of 70% ethanol for reflux extraction for 1.0 hour, extract twice in total, combine the extracts, and recover ethanol . Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of the drug solution of 1.15 (measured at 60°C). The concentrated solution is prepared by a...

Embodiment 3

[0022] Embodiment 3 Capsule preparation of the present invention

[0023] The composition of the pharmaceutical composition: Poria cocos 100g, coix seed 200g, polyporus 150g, gorgon fruit 200g, Su stem 150g, old pumpkin pedicle 100g, roasted licorice 100g.

[0024] Preparation:

[0025] (1) The above seven herbs, Poria cocos, Coix seed, Polyporus cocos, Gorgon seed, Perilla stem, Old pumpkin stalk, Zhigancao, add 10 times the amount of 70% ethanol for reflux extraction for 1.0 hour, extract twice in total, combine the extracts, and recover ethanol . Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of the drug solution of 1.15 (measured at 60°C). The concentrated solution is prepare...

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition for preventing ovarian hyperstimulation syndrome (OHSS). The traditional Chinese medicine composition is prepared from the following medicinal raw materials in parts by weight: 100-300 parts of poria cocos, 200-500 parts of coix seed, 150-450 parts of grifola, 200-500 parts of gordon euryale seed, 150-450 parts of caulis perllae, 100-300 parts of old pumpkin stalks and 100-300 parts of honey-fried licorice root. The traditional Chinese medicine composition is supported by solid Chinese medicine gynecology department classical theory and is reasonable in component ratio; the traditional Chinese medicine composition has a definite curative effect and no toxic or side effects, is capable of obviously reducing the occurrence rate of OHSS and obviously increasing the clinical pregnancy rate, and is safe to take. The herbal medicines in the traditional Chinese medicine composition are few, so that the quality control is easy, and meanwhile, the cost is low; the herbal medicines can be applied in preparation of the traditional Chinese medicine composition for preventing the OHSS in vitro fertilization and embryo transfer.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine composition, and relates to a traditional Chinese medicine composition for preventing ovarian hyperstimulation syndrome in in vitro fertilization-embryo transfer, which can be used in the preparation of medicines for preventing ovarian hyperstimulation syndrome in in vitro fertilization-embryo transfer . Background technique [0002] Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication caused by hyperstimulation of ovulation. Assisted reproductive technology has developed vigorously for more than 30 years, and the technology is becoming more and more mature, but the overall incidence of ovarian hyperstimulation syndrome caused by it is about 20%, of which 20%-35% are mild and 3%-6% are moderate , Severe 0.1% to 2%, severe cases may be life-threatening without proper treatment. [0003] Traditional Chinese medicine believes that ovarian hyperstimulation syndrome belongs to the c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61K9/48A61K9/16A61K9/20A61K9/14A61P15/08
Inventor 曲凡黄荷凤徐键周珏朱依敏胡燕军杨东霞顾颖尔
Owner ZHEJIANG UNIV
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