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Preparation method of theophylline

A technology of theophylline and tea, applied in the field of preparation of natural theophylline, achieving the effects of low requirements, short preparation cycle and simple operation

Inactive Publication Date: 2014-08-20
CHONGZHOU HERUI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on the preparation process of theophylline in tea

Method used

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Experimental program
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Effect test

Embodiment 1

[0026] The invention provides a kind of preparation method of theophylline, comprises the following steps:

[0027] (1) Extraction of theophylline

[0028] Get dry theophylline 2kg, prepare the KCl solution whose mass fraction of 8 times volume is 3.0%, and adjust the pH value of the chloride salt solution to 2, when adjusting the pH value of the KCl solution, the acid used is hydrochloric acid, extract 2 times, 48 ​​hours each time, combine the extracts and discard the drug residues;

[0029] (2) Enrichment of theophylline

[0030] The combined extracts are adsorbed by non-polar polystyrene macroporous adsorption resin column chromatography. The macroporous resin is D101 macroporous resin, and the volume of the macroporous resin is 1Kg to the weight ratio of the dry tea medicinal material: 1L, the adsorption rate is controlled at 2.0BV / h; after the adsorption is completed, first use 1.0BV of water to elute to remove impurities; then use 2.5BV of hydrophilic solvent to elute...

Embodiment 2

[0035] A preparation method of theophylline monomer, comprising the following steps:

[0036] (1) Extraction of theophylline Take 2 kg of dry tea leaves, prepare 10 times the volume of NaCl solution with a mass fraction of 4.0%, and adjust the pH value of the chloride salt solution to 2.5. When adjusting the pH value of the chloride salt solution, the The acid used is sulfuric acid, extracted twice, each time for 48 hours, the extracts were combined, and the drug residues were discarded;

[0037] (2) Enrichment of theophylline

[0038] The combined extract is adsorbed by non-polar polystyrene type macroporous adsorption resin column chromatography, the model of this macroporous adsorption resin is AB-8 type macroporous resin, the volume of macroporous adsorption resin and the weight ratio of dry tea leaves are 1Kg : 1.25L, the adsorption rate is controlled at 2.5BV / h; after the adsorption is completed, first wash with 1.0BV of water to remove impurities; then use 3.0BV of hyd...

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Abstract

The invention provides a preparation method of theophylline. The preparation method comprises the following steps: A, extracting theophylline, namely preparing a chlorine salt solution, and soaking tea leaf medicinal materials in the chlorine salt solution to extract theophylline; B, enriching theophylline, namely adsorbing extracting liquid by adopting non-polar polystyrene type macroporous adsorption resin column chromatography, after adsorbing, eluting, collecting eluting liquid, and performing reduced pressure concentration to obtain extract; C, purifying, namely performing alumina column chromatography on the extract, eluting, collecting eluting liquid, performing reduced pressure concentration, and refrigerating, crystallizing, filtering and drying concentrated liquid to obtain theophylline compounds. According to the method, a large quantity of high-quality theophylline compounds can be obtained through the four steps of extracting by the chlorine salt solution, enriching by macroporous adsorption resin, performing alumina column chromatography and crystallizing; the four steps are mild in condition and low in requirement, and the preparation cycle is short; the process is simple, the operation is simple and convenient, the requirement for the technical level of operators is low, and the industrialized popularization is facilitated.

Description

technical field [0001] The invention relates to a preparation method of natural theophylline, which belongs to the technical field of tea deep processing. Background technique [0002] Theophylline is a methyl purine compound and an important component of tea. It can stimulate the central nervous system, dilate blood vessels, speed up blood circulation, enhance muscle contraction, and strengthen the heart. It is also a good diuretic, which can strengthen kidney function, facilitate urination, and excrete toxins and waste from the kidney as soon as possible. Therefore, tea can prevent kidney disease and stone disease. Theophylline's function is mainly to dissolve fat, and has the effect of eliminating indigestion and greasy. This is the reason why drinking tea can lose weight, and the effect is more significant. Therefore, the extraction and separation process development of high-purity theophylline is of great significance. There is no report on the preparation process of...

Claims

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Application Information

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IPC IPC(8): C07D473/08
CPCC07D473/08
Inventor 黄帅
Owner CHONGZHOU HERUI TECH
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