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Esomeprazole magnesium suspension tablet and preparation method thereof

A technology for esomeprazole magnesium and esomeprazole magnesium pellets is applied in the field of esomeprazole magnesium suspension tablets and the preparation thereof, and can solve the problems of large packaging, dose difference and the like, and achieve accurate and accurate dose distribution. Facilitates distribution and overcomes inaccurate dosing effects

Inactive Publication Date: 2014-09-10
杭州新诺华医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, each single-dose package is relatively large, and more fillers and auxiliary materials need to be added to solve the dose difference caused by granule packaging

Method used

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Embodiment 3

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Abstract

The invention provides an esomeprazole magnesium suspension tablet which is prepared by mixing and tabletting an esomeprazole pill, a filler, corrigent, a disintegrating agent, a suspending agent, a lubricant and the like, wherein the esomeprazole pill is prepared by carrying the medicine in a pill core, wrapping an isolating layer and wrapping an enteric coating. Because of nicking, the esomeprazole magnesium suspension tablet can be torn apart for taking; a small pill tabletting process is adopted, the divided dose is accurate, the enteric effect of the pill is not affected after the tablet is torn apart, the tablet can be reasonably taken according to the age and the weight of children, and the clinical compliance is improved. The esomeprazole magnesium suspension tablet provided by the invention can be rapidly dispersed into suspension, is beneficial for distribution of the medicine in gastrointestinal tracts, can improve the bioavailability of the medicine, and is also applicable to patients with dysphagia.

Description

technical field The invention relates to the field of pharmaceutical preparations, in particular to an esomeprazole magnesium suspension tablet and a preparation method thereof. Background technique Esomeprazole (Esomepmzole, EMZ), is the world's first single-isomer proton pump inhibitor (I-PPI) developed by AstraZeneca, and is the S-type optical isomer of omeprazole. Compared with omeprazole, its oral hepatic metabolism rate is lower. The blood concentration and bioavailability are higher, and the acid suppression effect is stronger, and it also has a certain protective effect on the gastric mucosa. It is mainly used for the treatment of gastroesophageal reflux disease, Hp (Helicobacter pylori) positive peptic ulcer and gastric acid For related digestive system disorders, esomeprazole is currently the drug of choice for the treatment of gastric acid-related diseases. At present, only oral esomeprazole magnesium enteric-coated tablets are listed on the market, which are p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4439A61P1/04
Inventor 姚成志姜新东石晓宝
Owner 杭州新诺华医药有限公司
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