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A kind of astragalus wall-breaking preparation

A technology of Astragalus membranaceus preparations, which is applied in the field of Astragalus membranaceus wall-breaking preparations, can solve the problems of loss of active ingredients, easy moisture absorption, increase in powder specific surface area, etc., and achieves the advantages of being easy to drink with warm water, easy to disintegrate and disperse, and strong stability of the finished product Effect

Active Publication Date: 2018-03-16
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using the traditional decoction method, it is easy to destroy its heat-sensitive components. On the other hand, the decoction of the active ingredients is not complete, resulting in the loss of active ingredients.
The preparation of astragalus into superfine powder of astragalus is beneficial to improve the utilization rate of active ingredients, but at the same time, due to the increase of powder specific surface area, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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  • A kind of astragalus wall-breaking preparation
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  • A kind of astragalus wall-breaking preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take the medicinal material of Astragalus membranaceus, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particle size of the ultrafine powder is less than or equal to 45 μm, and add ethanol-water solution (the mass fraction of ethanol is 20% ) soft material by wet method, the ratio of solution to superfine powder is 0.6︰1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules , the wet granules were placed in a hot air circulation oven, the drying temperature was set at 85°C, and dried for 2.5 hours until dry, and the astragalus wall-broken preparation was obtained after sieving the whole granules.

[0024]

[0025] Note: The full score is 10.

Embodiment 2

[0027] Take the medicinal material of Astragalus membranaceus, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particle size of the ultrafine powder is less than or equal to 45 μm, and add ethanol-water solution (the mass fraction of ethanol is 40% ) soft material by wet method, the ratio of solution to superfine powder is 0.9︰1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 70r / min, and the extrusion force is 0.9MPa to make wet Granules, wet granules are transferred to a vacuum microwave drying oven, set the drying temperature to 45°C, and dried for 0.75h until dry.

[0028]

[0029] Note: The full score is 10.

Embodiment 3

[0031] Take the medicinal material of Astragalus membranaceus, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 45 μm, and add ethanol-water solution (the mass fraction of ethanol is 60% ) soft material by wet method, the ratio of solution to superfine powder is 1.0︰1 (by weight), after mixing, pre-installed 30-mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet Granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 85°C, and dried for 2.5 hours to dryness.

[0032]

[0033] Note: The full score is 10.

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Abstract

The invention relates to a traditional Chinese medicine preparation, in particular to a wall-breaking preparation of Astragalus membranaceus. According to the invention, astragalus is crushed into ultra-fine powder, further granulated by ethanol-water wet method, extruded and dried at a certain speed, and the prepared astragalus wall-broken preparation has high bioavailability, Moreover, the preparation has strong stability and good disintegration.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a wall-broken preparation of Astragalus membranaceus. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality of the drug increases eff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K36/481A61K9/16A61J3/00A61K125/00
Inventor 成金乐赖智填梁学良陈勇军乔卫林
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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