Preparation method of American ginseng wall-broken preparation

A technology of American ginseng and preparations, which is applied in the field of preparation of American ginseng wall-broken preparations, can solve the problems of decoction or incomplete absorption of active ingredients, increase of powder specific surface area, loss of active ingredients, etc. The effect of strong product stability

Active Publication Date: 2014-09-24
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional decoction or direct swallowing method may easily cause incomplete decoction or absorption of active ingredients, resulting in the loss of active ingredients, thereby reducing drug efficacy and wasting resources
The preparation of red ginseng into red ginseng superfine powder is beneficial to improve the utilization rate of active ingredients, but at the same time, due to the increase of powder specific surface area, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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  • Preparation method of American ginseng wall-broken preparation
  • Preparation method of American ginseng wall-broken preparation
  • Preparation method of American ginseng wall-broken preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Take the clean medicinal material of American ginseng, coarsely pulverize it into a coarse powder of about 100 meshes, and superfinely pulverize it into a powder with a particle size of 90% or less than 30 μm in the superfine powder, add ethanol-water solution (the mass fraction of ethanol is 50%) to wet The soft material is made by law, the ratio of solution to superfine powder is 0.3:1 (by weight), after mixing, it is pre-installed with a 10-mesh sieve, and the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules. Transpose it in a hot air circulation oven, set the drying temperature to 85°C, dry for 2.5 hours until dry, and sieve the whole grain to obtain the American ginseng wall-broken preparation.

[0039]

[0040] Note: The full score is 10.

Embodiment 2

[0042] Take the clean medicinal material of American ginseng, coarsely pulverize it into a coarse powder of about 100 meshes, and superfinely pulverize it into a powder in which 90% of the particles in the superfine powder have a particle size less than or equal to 30 μm, add ethanol-water solution (the mass fraction of ethanol is 60%) to wet The soft material is made by law, the ratio of solution to superfine powder is 0.5:1 (by weight), after mixing, it is pre-installed with a 10-mesh sieve, and the extrusion speed is 50r / min, and the extrusion force is 0.8MPa to make wet granules. The granules were transposed into a vacuum microwave drying oven, the drying temperature was set at 45° C., and dried for 0.75 h until dry.

[0043]

[0044] Note: The full score is 10.

Embodiment 3

[0046] Take the clean medicinal material of American ginseng, coarsely pulverize it into a coarse powder of about 100 meshes, and superfinely pulverize it into a powder with a particle size of 90% or less than 30 μm in the superfine powder, add ethanol-water solution (90% ethanol mass fraction) to wet The soft material is made by law, the ratio of solution to superfine powder is 0.7:1 (by weight), after mixing, it is pre-installed with a 30-mesh sieve, and the extrusion speed is 60r / min, and the extrusion force is 0.4MPa to make wet granules. The granules were transposed into a hot air circulation oven, set the drying temperature at 85°C, dried for 2.5 hours until dry, and the American ginseng wall-broken preparation was obtained after the granules were sized and sieved.

[0047]

[0048] Note: The full score is 10.

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Abstract

The invention relates to a Chinese medicine preparation, and in particular relates to an American ginseng wall-broken preparation. The American ginseng wall-broken preparation is prepared as follows: crushing American ginseng into wall-broken powder, then on the basis of quality control of an ethanol solution and the wall-broken powder, granulating by use of an ethanol-water wet method, extruding for forming at a certain rotating speed and drying, the method is high in granulation rate, and the prepared American ginseng wall-broken preparation is high in bioavailability, strong in stability, and good in disintegration.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation method of American ginseng wall-broken preparation. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/16A61K47/10A61J3/00A61K125/00
Inventor 成金乐赖智填梁学良苏观凤钱锦花
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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