A kind of purification process of hyaluronic acid

A technology of hyaluronic acid and process is applied in the field of purification technology of hyaluronic acid, can solve problems such as being insoluble in difficulty, and achieve the effects of reducing production cost, high yield and easy production control.

Active Publication Date: 2016-04-13
SHANDONG AWA BIOPHARM
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AI Technical Summary

Problems solved by technology

Some hyaluronic acid is fibrous in form and difficult to dissolve

Method used

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Embodiment １

[0038] A kind of hyaluronic acid purification technical scheme of the present invention is, a kind of Streptococcus zooepidemicus ( Streptococcus zooepidemicus ) AWA008, which was preserved in the General Microorganism Center of China Microbiological Culture Collection Management Committee, its preservation number is: CGMCCNo.9111, and the preservation date is April 29, 2014.

[0039] At present, the Streptococcus zooepidemicus is preserved in the General Microbiology Center of the China Microbiological Culture Collection Management Committee, address: No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, postcode: 100101, and its preservation number is: CGMCCNo.9111, the Latin name of the strain text name is Streptococcus zooepidemicus , The reference microorganism (strain): AWA008, the date of deposit is April 29, 2014.

[0040] The characteristics of the Streptococcus zooepidemicus strain of the present invention are as follows: spherical or oval, arranged in chains...

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Abstract

The invention discloses a purification process of hyaluronic acid. The present invention removes impurities in hyaluronic acid by adding activated carbon, perlite, white diatomaceous earth, and EDTA combined with large plate and frame filtration technology. The additives are common and easy to obtain, the operation is relatively simple, and the impurity content is lower. The production is easy to control, suitable for large-scale industrial production, the yield is high, and the production cost is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of biological polysaccharide extraction, in particular to a purification process of hyaluronic acid. Background technique [0002] There are currently more than a dozen manufacturers of hyaluronic acid in China, and most of these companies use animal tissue extraction. The commonly used raw materials for extracting HA from animal tissues are cockscomb, umbilical cord and pigskin, etc. The main process includes dehydration, grinding, soaking, extraction, impurity removal, precipitation and separation. This method is characterized by a simple process flow and is suitable for small-scale production where raw material sources are dispersed. However, due to the limited raw materials and the low content of HA in the raw materials, HA also coexists with mucopolysaccharides such as chondroitin sulfate in biological tissues, resulting in low yield, difficult purification, high cost, poor product quality, and difficu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08C12P19/26C12R1/46
Inventor 韩秀云
Owner SHANDONG AWA BIOPHARM
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