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Coreopsis tinctoria nutt extract and application thereof

An extract, the technology of snow chrysanthemum, applied in the field of snow chrysanthemum extract and its application, snow chrysanthemum extract and its application in the preparation of drugs for the treatment of hyperlipidemia and anti-oxidation, can solve the problem that it is difficult to ensure that the snow chrysanthemum extract Stability and effectiveness of pharmacological efficacy and other issues, to achieve the effect of small drug dosage, stable efficacy and high purity

Inactive Publication Date: 2014-12-03
南京三谷生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current research reports mainly focus on the research and verification of the pharmacological activity of snow chrysanthemum, which is generally carried out by using the snow chrysanthemum extract, lacking the analysis and identification of the active ingredients in the extract, so it is difficult to guarantee the stability and the pharmacological efficacy of the snow chrysanthemum extract. Effectiveness needs to be further studied

Method used

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  • Coreopsis tinctoria nutt extract and application thereof
  • Coreopsis tinctoria nutt extract and application thereof
  • Coreopsis tinctoria nutt extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: the preparation of snow chrysanthemum extract

[0022] Dried snow chrysanthemum (Coreopsis tinctoria, place of origin: Dabancheng, Xinjiang, batch 130501) flowers 1.0kg, 20L 30% ethanol aqueous solution reflux extraction twice, each time 1h, combined the two extracts, filtered, concentrated and recovered under reduced pressure Ethanol, add appropriate amount of water to dilute to 3.0L; choose AB-8 resin column (100cm×10cm i.d., column volume 2.0L / BV), after loading the sample, water 6BV, 10% ethanol 3BV, 75% ethanol 4BV, 95% ethanol 2BV elution, the flow rate is 1.5-2BV / h; the 75% ethanol elution part is collected, concentrated, and dried to obtain 115g of refined snow chrysanthemum total flavonoids extract (XJE). As detected by HPLC, the specific experimental conditions are the same as those in the qualitative and quantitative analysis of flavonoids in Example 5XJE, and the contents of maritin and flavonomarin in the XJE extract are 17.1% and 26.4%, respe...

Embodiment 2

[0023] Embodiment 2: the preparation of snow chrysanthemum extract

[0024] Dried Snow Chrysanthemum Flos 1.0kg was extracted twice through 20 times of 50% ethanol aqueous solution reflux, and all the other extraction and refining methods were the same as in Example 1 to obtain 104g of refined Snow Chrysanthemum Total Flavonoids Extract (XJE). As detected by HPLC, the specific experimental conditions are the same as those in the qualitative and quantitative analysis of flavonoids in Example 5 XJE, and the contents of maritin and flavonomarin in the XJE extract are 24.3% and 18.7%, respectively.

Embodiment 3

[0025] Embodiment 3: the preparation of snow chrysanthemum extract

[0026] 1.0 kg of dried snow chrysanthemum was extracted twice through reflux of 20 times of 75% ethanol aqueous solution, and all the other extraction and refining methods were the same as in Example 1 to obtain 104 g of refined snow chrysanthemum total flavonoids extract (XJE). As detected by HPLC, the specific experimental conditions are the same as those in the qualitative and quantitative analysis of flavonoids in Example 5 XJE. The contents of maritin and flavonomarin in the XJE extract are 26.1% and 11.5%, respectively.

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Abstract

The invention discloses a coreopsis tinctoria nutt extract and application of the coreopsis tinctoria nutt extract in preparation of medicines for treating hyperlipemia and anti-oxidation medicines. A method for preparing the coreopsis tinctoria nutt extract comprises the following steps: performing reflux extraction on a coreopsis tinctoria nutt medicinal material for 2-3 times by 12-25 times of 30-75% ethanol the amount of which is 12-25 times of the amount of the coreopsis tinctoria nutt medicinal material; mixing extract liquids, and concentrating to obtain extracting concentrate; diluting the extracting concentrate by water; refining by an AB-8 macroporous resin; sequentially eluting by water, 10% ethanol, 50-75% ethanol and 95% ethanol, and collecting the part eluted by 50-75% ethanol; concentrating and drying. The coreopsis tinctoria nutt extract comprises 10 flavones serving as main components, wherein the total content of marein and flavanomarein is more than 10 percent. Animal in-vivo experiments indicate that the coreopsis tinctoria nutt extract has a certain blood-fat regulating effect; and in-vitro anti-free radical scavenging experiments indicate that the coreopsis tinctoria nutt extract has a certain anti-oxidation effect, and flavanomarein, marein and the like are main anti-oxidation components.

Description

technical field [0001] The invention relates to a snow chrysanthemum extract and its application, more specifically, to a snow chrysanthemum extract and its application in the preparation of medicines for treating hyperlipidemia and anti-oxidation, belonging to the field of medicine and health food. Background technique [0002] Snow chrysanthemum is the flower of Coreopsis tinctoria Nutt., a plant of Compositae. This plant is native to North America and is distributed in the Kunlun Mountains in Hotan, Xinjiang. Coreopsis is called "Guri Qiayi" in Uighur. In the 1990s, folks in this area drank snow chrysanthemum as a special scented tea, which was believed to have the effect of lowering blood pressure, blood sugar and fat. With people's understanding and popularization of the efficacy of this medicinal material, snow chrysanthemum is known as a Xinjiang specialty with the same reputation as Tianshan snow lotus, and has been planted and promoted on a large scale. [0003] T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P3/06A61P39/06
Inventor 刘江云李雅丽谢辉高飞谢梅林木胡牙提·乌拉斯汉杨世林
Owner 南京三谷生物科技发展有限公司
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