New application of hesperetin

A technology of hesperetin and uses, applied in the field of new uses of hesperetin, can solve the problems that the use of hesperetin has not yet been reported and the like

Inactive Publication Date: 2014-12-24
NATURAL MEDICINE INST OF ZHEJIANG YANGSHENGTANG
View PDF3 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an important active substance in traditional Chinese medicine, hesperetin has many important biological and pharmacodynamic activities, mainly including anti-oxidation, anti-inflammation, blood lipid lowering, cardiovascular protection, anti-cancer and many other effects. The use of hesperetin in improving skin microcirculation has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New application of hesperetin
  • New application of hesperetin
  • New application of hesperetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1: Observation of the effect of topical application of hesperetin on skin microcirculation with laser Doppler

[0070] Test method for promoting microcirculation: take a male Japanese white rabbit with a body weight of 3.0-3.5kg, and after shaving the back, use a marker pen to delineate 10 points for testing blood flow in the hairless area of ​​the rabbit, 5 points on the left and right sides, Draw dots to avoid large blood vessels; before applying samples, use laser Doppler blood flowmeter to measure the basic blood flow value of 10 points of experimental rabbits in each group. solution (three groups of animals, the concentration of the drug solution is 0.5%, 1%, and 2%, respectively, and the dosage for each animal is 0.1 ml), and each concentration sample is paralleled with 3 rabbits. Oral 2% medicinal liquid in a similar way, the dosage is 100 times that of the 2% medicinal liquid smear group. Use laser Doppler blood flowmeter to measure the blood flow val...

Embodiment 2

[0075] Embodiment 2: the effect of hesperetin to dispel eye dark circles

[0076] Methods: In this study, the two formulas were used in the comparison test on both sides of the eyes for 8 weeks.

[0077] In this study, 50 volunteers with moderate to severe dark circles were recruited to ensure that the effective number of each paired comparison group was 15. Randomly distribute among the subjects and use left / right balance, apply the composition containing hesperetin on one side of the eye, and apply the composition without hesperetin on the other side, and last for 8 weeks. Efficacy evaluation was carried out at 0 week (before treatment), 2 weeks, 4 weeks, 6 weeks and 8 weeks.

[0078] Efficacy evaluation method: The eye images of the subjects were taken on the 0th day of the test as reference data, and the images were taken at the 2nd, 4th, 6th and 8th weeks of the test. Use photoshop software Lab system for chromaticity analysis and calculation. The L value represents t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to new application of hesperetin. Specifically, the invention relates to application of hesperetin or a plant extract containing hesperetin in preparation of a product used for improving and/or promoting skin microcirculation or eliminating and/or alleviating symptoms or morbid states related to poor skin microcirculation. The invention also relates to a composition containing effective dose of hesperetin or plant extract containing hesperetin and a method for improving and/or promoting skin microcirculation or eliminating and/or alleviating symptoms or morbid states related to the poor skin microcirculation by adopting hesperetin. The invention shows that hesperetin can be beneficial to the skin microcirculation, especially the skin microcirculation of eyes.

Description

[0001] The present invention is a divisional application of the parent application whose application number is 201010231389.2. The application date of the parent application is July 20, 2010, and the invention title is "New Application of Hesperetin". technical field [0002] The present invention relates to the new use of hesperetin, especially the new use in cosmetics, more particularly the role of hesperetin as a chemical component for improving skin microcirculation, especially the new use in removing dark circles around the eyes . Background technique [0003] The structure of human eye skin is different from other parts of human skin. First of all, above the cheekbones around the eyes and on both sides of the bridge of the nose are the "delivery sites" of blood vessels and lymph. This part is the place where facial venules meet, and blood vessels Very thin and rich, if the eye microcirculation is insufficient, it will lead to poor blood circulation or tissue edema, res...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61Q19/00
Inventor 胡柳蓝红英
Owner NATURAL MEDICINE INST OF ZHEJIANG YANGSHENGTANG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap