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Application of vietnamese sophora root polysaccharide extract in protection and treatment on liver injury caused by acetaminophen

A technology of paracetamol and rhizome root extract, which is applied to the application field of rhizoma rhizome polysaccharide extract in the protection and treatment of acetaminophen-induced liver damage

Inactive Publication Date: 2014-12-24
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no drug that can effectively and completely block the occurrence of liver injury, and there is no report on the use of mountain bean root extract and / or mountain bean root polysaccharides against acetaminophen-induced liver injury

Method used

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  • Application of vietnamese sophora root polysaccharide extract in protection and treatment on liver injury caused by acetaminophen
  • Application of vietnamese sophora root polysaccharide extract in protection and treatment on liver injury caused by acetaminophen
  • Application of vietnamese sophora root polysaccharide extract in protection and treatment on liver injury caused by acetaminophen

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Embodiment Construction

[0028] The above-mentioned content of the present invention will be further described in detail below through specific embodiments, but it should not be understood that the scope of the above-mentioned subject of the present invention is limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.

[0029] Example Therapeutic effect of mountain bean root extract on acute liver injury caused by acetaminophen

[0030] 1. Experimental method

[0031] (1) Preparation method of the root of the mountain bean

[0032] The water extraction and alcohol precipitation method optimized and improved by the pre-experiment was used for extraction and separation. Weigh 50g of dry bean root medicinal powder, add 150mL preheated distilled water several times, soak in 45°C water bath for 20min, then transfer to a porcelain dish with 450w intermittent microwave for 1min×12 times, replenish lost wa...

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Abstract

The invention relates to novel application of a vietnamese sophora root polysaccharide extract, in particular to a polysaccharide extract obtained from a vietnamese sophora root medicinal material through extraction and separation and used for protection and treatment on liver injury caused by acetaminophen. The application is characterized in that the protection and treatment effect of the vietnamese sophora root polysaccharide extract, on the liver injury caused by the acetaminophen, is superior to the effect of clinical medicine N-acetylcysteine, action mechanism is that the acute liver injury caused by the acetaminophen is relieved under the multiple effects of oxidation resistance of the vietnamese sophora root extract, added mitochondrion uncoupling protein 2 expression and the like, and clinic protection and treatment on the liver injury caused by excessive wrongly-taken acetaminophen is facilitated.

Description

technical field [0001] The invention relates to a new application of the polysaccharide extract of the root of the mountain bean, in particular, the extract of the polysaccharide is isolated from the medicinal material of the root of the mountain bean, and is used for protecting and treating liver damage caused by acetaminophen. Background technique [0002] Acetaminophen (APAP), also known as paracetamol, is a commonly used antipyretic and analgesic drug, which is widely used clinically and is effective and safe when used in clinical doses. However, acetaminophen is a hepatotoxic substance when used in excess. Overdose can cause liver damage. It forms toxic metabolites through biotransformation and then causes a series of liver cell dysfunction, leading to liver damage and liver poisoning. lead to liver failure and even death. APAP is mainly metabolized in the liver. About 60% of APAP is combined with gluconic acid under the action of glucuronosyltransferase, and about 30%...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K36/489A61P1/16A61P39/06A61K125/00
Inventor 栾立标苏丹
Owner CHINA PHARM UNIV
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