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Application of arundic acid in preparation of medicine for treating hepatic fibrosis

A technology of liver fibrosis and alenic acid, which is applied in the field of alenic acid for the treatment of liver fibrosis, can solve the problems of lack of drugs for liver fibrosis, and no liver fibrosis has been seen yet.

Inactive Publication Date: 2021-04-02
YOUJIA (HANGZHOU) BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a lack of drugs for the treatment of liver injury and liver fibrosis
There is no research report on the treatment of liver fibrosis with Arundic acid

Method used

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  • Application of arundic acid in preparation of medicine for treating hepatic fibrosis
  • Application of arundic acid in preparation of medicine for treating hepatic fibrosis
  • Application of arundic acid in preparation of medicine for treating hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Effect of Alenic Acid on Carbon Tetrachloride-Induced Acute Liver Injury in Mice, and Comparison with the Positive Drug, Silibinin

[0032] 1. Materials and methods

[0033] 56 male C57BL / 6 mice (Victorian Lihua), the weight of the mice at the beginning of the experiment was 24 + 1g. Adaptive rearing for one week under the culture conditions of temperature 24-26°C, humidity 60%, light and dark for 12 hours each. Mix CCl with a volume ratio of 1:3 4 and olive oil, except for the control group, each male C57BL / 6 mouse was intraperitoneally injected with 0.05mL / 10g (body weight) CCl 4 olive oil solution, and the control group was intraperitoneally injected with an equal volume of olive oil. 24 hours after model establishment, alenic acid and silibinin were administered according to the following groups. After 48 hours, mice were sacrificed and samples were taken. Serum was collected from the mice, and the livers were cryopreserved and fixed with 4% paraforma...

Embodiment 2

[0047] Example 2: Effect of alenic acid on carbon tetrachloride-induced chronic liver fibrosis model in mice, and comparison with the positive drug silibinin

[0048] 1. Materials and methods

[0049] 56 male C57BL / 6 mice (Victorian Lihua), the weight of the mice at the beginning of the experiment was 20 + 1g. Adaptive rearing for one week under the culture conditions of temperature 24-26°C, humidity 60%, light and dark for 12 hours each. Mix CCl with a volume ratio of 2:5 4 and olive oil, except for the control group, each male C57BL / 6 mouse was intraperitoneally injected with 0.02ml / 10g (body weight) CCl every three days 4 olive oil solution, and the control group was intraperitoneally injected with the same volume of olive oil, and the model continued for 6 weeks. The test drug was administered 2 weeks after modeling, continued for 4 weeks (28 days), and ended after 6 weeks.

[0050] 2. Administration method

[0051] With embodiment 1.

[0052] 3. Group design

[00...

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PUM

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Abstract

The invention relates to an application of arundic acid in treatment of liver fibrosis or liver injury. Aiming at the current situation that no effective means for treating the acute liver injury andthe hepatic fibrosis exists at present, the inventor of the invention finds that arundic acid can play a treatment role in a carbon tetrachloride-induced acute liver injury and chronic hepatic fibrosis model through deep research, and can obviously relieve the acute liver injury and the hepatic fibrosis. In the experiment process, no obvious toxicity is found.

Description

technical field [0001] The invention relates to the field of medical application, in particular to the application of alenic acid in treating liver fibrosis. Background technique [0002] Hepatic fibrosis is the result of liver injury and is the abnormal proliferation of connective tissue in the liver caused by various pathogenic factors. Hepatic fibrosis may lead to liver dysfunction and is the main process of liver injury developing into other chronic diseases. It recruits inflammatory cells and activates hepatic stellate cells (HSCs) in response to chronic injury, causing accumulation of extracellular matrix. Steatosis often coexists with hepatitis and hepatocellular damage. Increased oxidative stress is a common cause of fibrosis in all chronic liver diseases, regardless of etiology. Damaged hepatocytes, HSCs, and infiltrating inflammatory cells are the main sources of reactive oxygen species (ROS). Indeed, oxidative stress will induce the recruitment of inflammatory ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/663A61P1/16
CPCA61K31/663A61P1/16A61P29/00A61P11/00Y02A50/30
Inventor 崔文浩赵成江王猛郑智田欢栋
Owner YOUJIA (HANGZHOU) BIOMEDICAL TECH CO LTD
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