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Malus halliana leaf extract, extraction method and application thereof

A technology of crabapple and leaf extract, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., and can solve the problems such as the unclear medicinal value of crabapple flower and crabapple

Active Publication Date: 2014-12-24
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the other pharmacological effects of the flower of the crabapple or the medicinal value of other parts of the crabapple are not yet clear

Method used

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  • Malus halliana leaf extract, extraction method and application thereof
  • Malus halliana leaf extract, extraction method and application thereof
  • Malus halliana leaf extract, extraction method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] An extract of crabapple leaves, which is the ethyl acetate part of crabapple leaves. The ethyl acetate part of the crabapple leaf is the ethyl acetate extract obtained by dispersing the ethanol extract of the crabapple leaf in water and extracting it with ethyl acetate.

[0024] Its corresponding extraction method includes the following steps:

[0025] (1) After natural drying and crushing of the leaves of Begonia chinensis, leaching with 60V% ethanol at room temperature for 3 times, 3 hours each time, combining the infusions, filtering and concentrating to obtain the ethanol extract.

[0026] (2) Disperse the ethanol extract of Crabapple leaves in water, extract with ethyl acetate, and evaporate the solvent to obtain ethyl acetate extract, which is the ethyl acetate part of Crabapple leaves.

[0027] The above-mentioned crabapple leaf extract is used to prepare antioxidants.

[0028] The above-mentioned crabapple leaf extract is used to prepare liver-protecting medic...

Embodiment 2

[0030] An extract of crabapple leaves, which is the n-butanol part of crabapple leaves. The n-butanol part of the leaves of the crabapple leaves is the n-butanol extract obtained by dispersing the ethanol extract of the leaves of the crabapple leaves in water and extracting them with n-butanol.

[0031] Its corresponding extraction method includes the following steps:

[0032] (1) After dried and crushed, the leaves of Begonia chinensis are extracted twice with 80V% ethanol at 70°C for 1 hour each time. The extracts are combined, filtered, and concentrated to obtain the ethanol extract.

[0033] (2) Disperse the ethanol extract of crabapple leaves in water, extract with ethyl acetate and n-butanol in sequence, evaporate the solvent, and the obtained n-butanol extract is the n-butanol part of crabapple leaves.

[0034] The above-mentioned crabapple leaf extract is used to prepare antioxidants.

[0035] The above-mentioned crabapple leaf extract is used to prepare liver-protec...

Embodiment 3

[0037] An extract of crabapple leaves, which is a mixture of n-butanol fractions and ethyl acetate fractions of crabapple leaves. Among them, the ethyl acetate part of the leaves of the crabapple leaves is the ethyl acetate extract obtained by dispersing the ethanol extract of the leaves of the crabapple leaves in water and extracting them with ethyl acetate; the n-butanol part is the extract of the leaves of the crabapple leaves The ethanol extract is dispersed in water and extracted with n-butanol to obtain n-butanol extract.

[0038] Its corresponding extraction method includes the following steps:

[0039] (1) After dried and pulverized, the leaves of Begonia chinensis are extracted twice with 70V% ethanol at 50°C for 2 hours each time. The extracts are combined, filtered and concentrated to obtain the ethanol extract.

[0040] (2) Disperse the ethanol extract of Crabapple leaves in water, extract with ethyl acetate and n-butanol in sequence, and evaporate the solvent, th...

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Abstract

The invention relates to a malus halliana leaf extract, an extraction method and an application thereof, and belongs to the field of pharmaceutical technology. The malus halliana leaf extract is n-butanol extract and / or ethyl acetate extract of the malus halliana leaf. The extraction method comprises the following steps of dispersing the ethanol extract of the malus halliana leaf in water; extracting with ethyl acetate and n-butanol successively; and volatilizing a solvent. The ethyl acetate extract is the ethyl acetate extract of the malus halliana leaf; and the n-butanol extract is the n-butanol extract of the malus halliana leaf. Experiments demonstrate that the malus halliana leaf extract provided by the invention can effectively clear DPPH and ABTS free radicals and reduce Fe<3+>, so that the malus halliana leaf extract can be used for preparing antioxidants. The extract can significantly reduce GPT and GOT content in serum of mice suffering from acute liver injury and MDA content in mice liver tissues and increase SOD activity, so that the extract can be used for preparing drugs for protecting the liver.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and specifically relates to an extract of crabapple leaves, and also relates to an extraction method and application of the extract. Background technique [0002] Malus halliana Koehne (Malus halliana Koehne) is a deciduous tree of the Rosaceae apple genus, distributed in Shaanxi, Sichuan, Jiangsu, Anhui, Zhejiang and Yunnan in mainland China. At present, domestic and foreign researches on Begonia Chuisi mainly focus on artificial cultivation, tissue culture regeneration, and classification of varieties, while the medicinal value of Begonia Chuisi is seldom involved. According to relevant records of traditional Chinese medicine, the flower of Chuisi crabapple can be used as medicine, which has the effect of regulating menstruation and blood. However, the other pharmacological effects of the flowers of the crabapple or the medicinal value of other parts of the crabapple are still unclear. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P39/06A61P1/16A61K127/00
Inventor 康文艺张伟彭涛尹震花孔祥密
Owner HENAN UNIVERSITY
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