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A kind of compound povidone-iodine disinfectant and preparation method thereof

A technology of povidone-iodine and disinfectant, which is applied in the field of compound povidone-iodine disinfectant and its preparation, can solve the problems of rising incidence, iodophor stability easily affected by temperature, iodine volatility and other problems, and achieve the elimination of Inflammatory edema, good bactericidal effect, product quality assurance effect

Active Publication Date: 2018-04-24
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, it has been reported in the literature that iodophor may cause an increase in the incidence of thyroid disease in female medical staff, which may be related to the volatility of iodine. Some studies have shown that the stability of iodophor is easily affected by temperature, and some literature has shown that the concentration of available iodine is relatively high. When it is high (>1000μg / L), it has an inhibitory effect on cell proliferation. Therefore, it is of great significance to carry out research on new povidone-iodine compound disinfection products and develop products with good quality and stable performance.

Method used

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  • A kind of compound povidone-iodine disinfectant and preparation method thereof
  • A kind of compound povidone-iodine disinfectant and preparation method thereof
  • A kind of compound povidone-iodine disinfectant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] prescription

[0025] Povidone-iodine (PVP-I) 50g Periplaneta americana alcohol extract (calculated as total amino acids) not less than 0.8g glycerin 150ml sorbic acid 2g sodium benzoate 3.5g potassium iodate 2g

[0026] Prepared into 1000ml

[0027] method

[0028] Get PVP-I 50g, Periplaneta americana extract (in total amino acids) is not less than 0.8g, add 80% of required amount of pure water, glycerin 150ml, potassium iodate 2g, sodium benzoate 3.5g and sorbic acid 2g, Heat to dissolve, filter, add water to the filtrate to 1000ml, stir well, sterilize, filter, fill, and obtain.

[0029] The compound povidone iodine disinfectant contains 5% povidone iodine in terms of effective iodine concentration, and contains no less than 0.8g per 1000ml of Periplaneta americana extract.

Embodiment 2

[0031] prescription

[0032] Povidone-iodine (PVP-I) 25g Periplaneta americana alcohol extract (calculated as total amino acids) not less than 0.8g glycerin 150ml Tween-801ml Potassium iodate 2g Sorbic acid 3g

[0033] Prepared into 1000ml

[0034] method

[0035] Get PVP-I 25g, Periplaneta americana extract (in total amino acids) not less than 0.8g, add 80% of the required amount of pure water, glycerin 150ml, potassium iodate 2g, sorbic acid 3g and Tween-801ml, heat Dissolve, filter, add water to the filtrate to 1000ml, stir well, sterilize, filter, fill, and obtain.

[0036] The compound povidone-iodine disinfectant contains 2.5% povidone-iodine in terms of available iodine concentration, and contains no less than 0.8g per 1000ml of Periplaneta americana extract.

Embodiment 3

[0038] prescription

[0039] Povidone-iodine (PVP-I) 10g Periplaneta americana alcohol extract (calculated as total amino acid) 0.8~0.9g Tween-805ml Potassium iodate 2g

[0040] Prepared into 1000ml

[0041] method

[0042] Get PVP-I10g, Periplaneta americana extract (in total amino acids) 0.85g, add 80% of the required amount of pure water, Tween 805ml and potassium iodate 2g, heat to dissolve, filter, add water to the filtrate to 1000ml, stir Homogenize, sterilize, filter, fill, and get ready.

[0043] The compound povidone-iodine disinfectant contains 1% povidone-iodine in terms of effective iodine concentration, and contains 0.8-0.9 g per 1000 ml of Periplaneta americana extract.

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Abstract

The invention provides a compound povidone-iodine disinfectant solution, which contains the following dosages of raw materials in every 1000ml disinfectant solution: 10-100g of povidone-iodine, more than 0.8g of Periplaneta americana extract in terms of total amino acids, and potassium iodate Appropriate amount, the balance is water. The invention also provides a preparation method of the disinfectant. The present invention combines the American cockroach ethanol extract with povidone-iodine, which not only has a good bactericidal effect, but also can promote the growth of granulation tissue, anti-inflammation and eliminate inflammatory edema, and the two form a compound povidone-iodine disinfectant The preparation can be used for disinfection and treatment of various wounds; in addition, the present invention has found that adding Periplaneta americana extract to povidone-iodine significantly increases the stability of povidone-iodine and provides guarantee for product quality.

Description

technical field [0001] The invention relates to a compound povidone-iodine disinfectant and a preparation method thereof. Background technique [0002] Periplaneta Americana (Periplaneta Americana) belongs to Insecta, Blattata, Blatidae, "cockroach" is its common name, first seen in "Compendium of Materia Medica Supplements", also known as Shijiang, slipworm, has survived on the earth for 3.5 It is one of the most vigorous, oldest, and most successful insect groups in the world. The main medicine of Periplaneta americana is lumps and accumulation, and it can benefit the blood vessels. External use can suppress sores, pull out toxins, eliminate decay, and promote muscle growth. Modern research shows that it also has good antibacterial effects. [0003] The main component of Kangfuxin liquid is the ethanol extract of the dried worm body of Periplaneta americana, which can benefit blood vessels, nourish yin and strengthen muscles. Modern medicine believes that Kangfuxin liquid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P31/04A61P17/02A61K31/79
Inventor 张廷模苏柘僮邹俊波
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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