Oil suspension containing doxycycline hydrochloride and flunixin meglumine and preparation method of oil suspension
The technology of flunixin meglumine and doxycycline is applied in the field of veterinary antibiotics and preparation, and can solve the problems of uneven administration of tablets and powder injections, low drug content in injections, and animal side effects.
Inactive Publication Date: 2015-01-14
QINGDAO VLAND BIOTECH INC
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Problems solved by technology
However, the administration of tablets and powder injections is uneven, and they are easily affected by the contents of the gastrointestinal tract, which affects the therapeutic effect
Ordinary doxycycline aqueous injections contain low drug content and often need to be administered repeatedly, usually once a day, which is likely to cause stress to animals, and the blood drug concentration curve is generally wavy, with obvious peaks in the blood drug concentration and troughs, which can also have some toxic side effects on animals
Method used
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example
[0022] Example: 20% doxycycline hydrochloride, flunixin meglumine oil suspension
[0023] 【Prescription】Doxycycline Hydrochloride 20%(W / V)
[0024] Flunixin Meglumine 2%(W / V)
[0025] Aluminum monostearate 0.5% (W / V)
[0026] Span80 0.2%(W / V)
[0027] Propyl gallate 0.05%(W / V)
[0028] Add tea oil for injection to 100% (V / V)
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Abstract
The invention belongs to the technical fields of veterinary antibiotics and preparation methods of the antibiotics and particularly relates to an oil suspension injection containing doxycycline hydrochloride and flunixin meglumine and a preparation method of the oil suspension injection. The oil suspension injection is composed of crude drugs (a) of doxycycline hydrochloride and flunixin meglumine, a suspending aid (b), a surfactant (c) and an antioxidant (d). The oil suspension injection containing doxycycline hydrochloride and flunixin meglumine, provided by the invention, is prepared by using a dispersion method and is a light yellow slightly-thick oil suspension. The oil suspension injection containing doxycycline hydrochloride and flunixin meglumine, researched by the invention, is good in stability and biocompatibility and can be used as a veterinary long-acting injection, the absorption time and the elimination half life are prolonged, and the time to peak is delayed.
Description
[0001] technical field [0002] The invention belongs to the technical field of veterinary antibiotics and preparation methods, in particular to an oil suspension containing doxycycline hydrochloride and flunixin meglumine and a preparation method thereof. The preparation method of the oil suspension of Nisin meglumine is prepared into a long-acting injection for animals. [0003] Background technique [0004] Doxycycline hydrochloride, also known as deoxyoxytetracycline hydrochloride and doxycycline hydrochloride, belongs to tetracycline drugs, and is used in veterinary medicine to treat gram-positive bacteria, negative bacteria and some chlamydia, mycoplasma and rickettsia , Diseases caused by spirochetes. [0005] Flunixin meglumine is a veterinary anti-inflammatory analgesic. Flunixin meglumine has antipyretic, anti-inflammatory and analgesic effects. It can significantly improve clinical symptoms and enhance the activity of antibiotics when used alone or in combinati...
Claims
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IPC IPC(8): A61K31/65A61K9/10A61P31/04A61P31/00A61P29/00A61K31/44
Inventor 栾明娜
Owner QINGDAO VLAND BIOTECH INC
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