Oil suspension containing doxycycline hydrochloride and flunixin meglumine and preparation method of oil suspension

Abstract

The invention belongs to the technical fields of veterinary antibiotics and preparation methods of the antibiotics and particularly relates to an oil suspension injection containing doxycycline hydrochloride and flunixin meglumine and a preparation method of the oil suspension injection. The oil suspension injection is composed of crude drugs (a) of doxycycline hydrochloride and flunixin meglumine, a suspending aid (b), a surfactant (c) and an antioxidant (d). The oil suspension injection containing doxycycline hydrochloride and flunixin meglumine, provided by the invention, is prepared by using a dispersion method and is a light yellow slightly-thick oil suspension. The oil suspension injection containing doxycycline hydrochloride and flunixin meglumine, researched by the invention, is good in stability and biocompatibility and can be used as a veterinary long-acting injection, the absorption time and the elimination half life are prolonged, and the time to peak is delayed.

Description

[0001] technical field [0002] The invention belongs to the technical field of veterinary antibiotics and preparation methods, in particular to an oil suspension containing doxycycline hydrochloride and flunixin meglumine and a preparation method thereof. The preparation method of the oil suspension of Nisin meglumine is prepared into a long-acting injection for animals. [0003] Background technique [0004] Doxycycline hydrochloride, also known as deoxyoxytetracycline hydrochloride and doxycycline hydrochloride, belongs to tetracycline drugs, and is used in veterinary medicine to treat gram-positive bacteria, negative bacteria and some chlamydia, mycoplasma and rickettsia , Diseases caused by spirochetes. [0005] Flunixin meglumine is a veterinary anti-inflammatory analgesic. Flunixin meglumine has antipyretic, anti-inflammatory and analgesic effects. It can significantly improve clinical symptoms and enhance the activity of antibiotics when used alone or in combinati...

AI Technical Summary

Problems solved by technology

However, the administration of tablets and powder injections is uneven, and they are easily affected by the contents of the gastrointestinal tract, which affects the therapeutic effect

Ordinary doxycycline aqueous injections contain low drug content and often need to b