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Suspending agent containing gentamicin sulfate and betamethasone valerate and preparation method of suspending agent

A technology of betamethasone valerate and gentamicin, applied in the field of veterinary anticoccidial drugs and preparation, can solve the problems of cartilage tissue being unable to repair itself, cartilage cells being too late to produce enough, etc.

Inactive Publication Date: 2015-01-14
QINGDAO VLAND BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cartilage repairs after wear and tear, but chondrocytes do not have time to produce a sufficient spongy matrix, so worn cartilage cannot repair itself

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example

[0022] Example: 5% gentamicin sulfate + betamethasone valerate aqueous suspension

[0023] [Prescription] Gentamicin Sulfate + Betamethasone Valerate 5+15% (W / V)

[0024] Tragacanth Gum 0.8%(W / V)

[0025] Propylene Glycol 10%(W / V)

[0026] Poloxamer 0.3%(W / V)

[0027] Sodium Benzoate 0.2%(W / V)

[0028] Add pure water to 100% (V / V)

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PUM

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Abstract

The invention belongs to the technical field of veterinary liquid suspending agents for treating arthritis and preparation methods of the veterinary liquid suspending agents and particularly relates to a suspending agent containing gentamicin sulfate and betamethasone valerate and a preparation method of the suspending agent. The suspending agent is composed of crude drugs (a) of gentamicin sulfate and betamethasone valerate, a suspending aid (b), a wetting agent (c), a preservative (d) and a preservative (e). The suspending agent containing gentamicin sulfate and betamethasone valerate, provided by the invention, is prepared by using a dispersion method and is a white-like slightly-thick water suspension. The suspending agent containing gentamicin sulfate and betamethasone valerate, researched by the invention, is good in stability and palatability, long in elimination half life and high in bioavailability and can be used as a veterinary oral preparation.

Description

technical field [0001] The invention belongs to the technical field of veterinary anticoccidiostats and preparation methods, and in particular relates to a preparation method of a suspending agent of gentamicin sulfate+betamethasone valerate. technical background [0002] Normal articular cartilage is white, smooth and translucent. It is composed of chondrocytes and a spongy matrix surrounding chondrocytes. The main components of this matrix are collagen, polysaccharide protein and water. In the early stage of osteoarthritis, the cartilage will appear yellow and opaque, and some parts of the surface will soften and become rough. [0003] As the disease progresses, this softened cartilage cracks and wears away, exposing the underlying hard bone. At the same time, the changed cartilage reorganizes and increases in stiffness, and the remaining cartilage begins to wear away. Eventually, osteophytes form in the joints. Cartilage repairs after wear and tear, but chondrocytes do...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61P19/02A61P19/08A61P33/02A61K31/573
CPCA61K31/7036A61K9/10A61K31/573
Inventor 刘元元
Owner QINGDAO VLAND BIOTECH INC
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